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Association of macular pigment optical density with retinal layer thicknesses in eyes with and without manifest primary open-angle glaucoma.
Lawler, Thomas; Mares, J A; Liu, Zhe; Thuruthumaly, Catherine; Etheridge, Tyler; Vajaranant, Thasarat S; Domalpally, Amitha; Hammond, Billy R; Wallace, Robert B; Tinker, Lesley F; Nalbandyan, Marine; Klein, Barbara E K; Liu, Yao.
Afiliación
  • Lawler T; Department of Nutritional Sciences, College of Agricultural & Life Sciences, University of Wisconsin, Madison, Wisconsin, USA.
  • Mares JA; Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, USA.
  • Liu Z; Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, USA.
  • Thuruthumaly C; Ophthalmology & Visual Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
  • Etheridge T; Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, USA.
  • Vajaranant TS; Department of Ophthalmology & Visual Sciences, University of Illinois, Chicago, Illinois, USA.
  • Domalpally A; Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, USA.
  • Hammond BR; Department of Psychology, University of Georgia, Athens, Georgia, USA.
  • Wallace RB; Department of Epidemiology, University of Iowa, Iowa City, Iowa, USA.
  • Tinker LF; Department of Cancer Prevention, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
  • Nalbandyan M; Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, USA.
  • Klein BEK; Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, USA.
  • Liu Y; Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, USA yao.liu2@wisc.edu.
BMJ Open Ophthalmol ; 8(1)2023 10.
Article en En | MEDLINE | ID: mdl-37890895
OBJECTIVE: To investigate associations between baseline macular pigment optical density (MPOD) and retinal layer thicknesses in eyes with and without manifest primary open-angle glaucoma (POAG) in the Carotenoids in Age-Related Eye Disease Study 2 (CAREDS2). METHODS AND ANALYSIS: MPOD was measured at CAREDS baseline (2001-2004) via heterochromatic flicker photometry (0.5° from foveal centre). Peripapillary retinal nerve fibre layer (RNFL), macular ganglion cell complex (GCC), ganglion cell layer (GCL), inner plexiform layer (IPL), and RNFL thicknesses were measured at CAREDS2 (2016-2019) via spectral-domain optical coherence tomography. Associations between MPOD and retinal thickness were assessed using multivariable linear regression. RESULTS: Among 742 eyes (379 participants), manifest POAG was identified in 50 eyes (32 participants). In eyes without manifest POAG, MPOD was positively associated with macular GCC, GCL and IPL thicknesses in the central subfield (P-trend ≤0.01), but not the inner or outer subfields. Among eyes with manifest POAG, MPOD was positively associated with macular GCC, GCL, IPL and RNFL in the central subfield (P-trend ≤0.03), but not the inner or outer subfields, and was positively associated with peripapillary RNFL thickness in the superior and temporal quadrants (P-trend≤0.006). CONCLUSION: We observed a positive association between MPOD and central subfield GCC thickness 15 years later. MPOD was positively associated with peripapillary RNFL superior and temporal quadrant thicknesses among eyes with manifest POAG. Our results linking low MPOD to retinal layers that are structural indicators of early glaucoma provide further evidence that carotenoids may be protective against manifest POAG.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glaucoma de Ángulo Abierto / Pigmento Macular / Mácula Lútea Límite: Humans Idioma: En Revista: BMJ Open Ophthalmol Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glaucoma de Ángulo Abierto / Pigmento Macular / Mácula Lútea Límite: Humans Idioma: En Revista: BMJ Open Ophthalmol Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido