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Normocephalic Children Exposed to Maternal Zika Virus Infection Do Not Have a Higher Risk of Neurodevelopmental Abnormalities around 24 Months of Age than Unexposed Children: A Controlled Study.
Godoi, Juannicelle T A M; Negrini, Silvia F B M; Aragon, Davi C; Rocha, Paulo R H; Amaral, Fabiana R; Negrini, Bento V M; Teixeira, Sara R; Yamamoto, Aparecida Y; Bettiol, Heloisa; Mussi-Pinhata, Marisa M.
Afiliación
  • Godoi JTAM; Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, Brazil, Av. Bandeirantes 3009, Campus USP, Ribeirão Preto CEP 14049-900, São Paulo, Brazil.
  • Negrini SFBM; Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, Brazil, Av. Bandeirantes 3009, Campus USP, Ribeirão Preto CEP 14049-900, São Paulo, Brazil.
  • Aragon DC; Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, Brazil, Av. Bandeirantes 3009, Campus USP, Ribeirão Preto CEP 14049-900, São Paulo, Brazil.
  • Rocha PRH; Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, Brazil, Av. Bandeirantes 3009, Campus USP, Ribeirão Preto CEP 14049-900, São Paulo, Brazil.
  • Amaral FR; Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, Brazil, Av. Bandeirantes 3009, Campus USP, Ribeirão Preto CEP 14049-900, São Paulo, Brazil.
  • Negrini BVM; Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, Brazil, Av. Bandeirantes 3009, Campus USP, Ribeirão Preto CEP 14049-900, São Paulo, Brazil.
  • Teixeira SR; Department of Imaging, Hematology and Oncology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto CEP 14049-900, São Paulo, Brazil.
  • Yamamoto AY; Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
  • Bettiol H; Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, Brazil, Av. Bandeirantes 3009, Campus USP, Ribeirão Preto CEP 14049-900, São Paulo, Brazil.
  • Mussi-Pinhata MM; Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, Brazil, Av. Bandeirantes 3009, Campus USP, Ribeirão Preto CEP 14049-900, São Paulo, Brazil.
Pathogens ; 12(10)2023 Oct 06.
Article en En | MEDLINE | ID: mdl-37887735
Although very few controlled studies are available, in utero Zika virus (ZIKV)-exposed children are considered at risk for neurodevelopmental abnormalities. We aimed to identify whether there is an excess risk of abnormalities in non-microcephalic children born to mothers with confirmed ZIKV infection compared with ZIKV-unexposed children from the same population. In a cross-sectional study nested in two larger cohorts, we compared 324 ZIKV-exposed children with 984 unexposed controls. Outcomes were assessed using the Bayley Screening Test III applied around 24 months of age. Relative risks for classifying children as emergent or at-risk for neurodevelopmental delay in at least one of five domains were calculated, adjusting for covariates. In four of the five domains, few children were classified as emergent (4-12%) or at-risk (0.3-2.16%) but for the expressive communication domain it was higher for emergent (19.1-42.9%). ZIKV-exposed children were half as frequently classified as emergent, including after adjusting for covariates [RR = 0.52 (CI 95% 0.40; 0.66)]. However, no difference was detected in the at-risk category [RR = 0.83 (CI 95% 0.48; 1.44)]. Normocephalic children exposed to the Zika virus during pregnancy do not have a higher risk of being classified as at risk for neurodevelopmental abnormalities at two years of age.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Pathogens Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Pathogens Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza