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Understanding ART Adherence among Adolescent Girls and Young Women in Western Kenya: A Cross-Sectional Study of Barriers and Facilitators.
Altamirano, Jonathan; Odero, Isdorah A; Omollo, Mevis; Awuonda, Eucabeth; Ondeng'e, Ken; Kang, Jennifer L; Behl, Rasika; Ndivo, Richard; Baiocchi, Michael; Barsosio, Hellen C; Sarnquist, Clea C.
Afiliación
  • Altamirano J; Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Odero IA; Kenya Medical Research Institute, Center for Global Health Research (KEMRI-CGHR), Kisumu 40100, Kenya.
  • Omollo M; Kenya Medical Research Institute, Center for Global Health Research (KEMRI-CGHR), Kisumu 40100, Kenya.
  • Awuonda E; Kenya Medical Research Institute, Center for Global Health Research (KEMRI-CGHR), Kisumu 40100, Kenya.
  • Ondeng'e K; Kenya Medical Research Institute, Center for Global Health Research (KEMRI-CGHR), Kisumu 40100, Kenya.
  • Kang JL; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Behl R; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Ndivo R; Kenya Medical Research Institute, Center for Global Health Research (KEMRI-CGHR), Kisumu 40100, Kenya.
  • Baiocchi M; Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Barsosio HC; Kenya Medical Research Institute, Center for Global Health Research (KEMRI-CGHR), Kisumu 40100, Kenya.
  • Sarnquist CC; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Int J Environ Res Public Health ; 20(20)2023 10 14.
Article en En | MEDLINE | ID: mdl-37887660
BACKGROUND: HIV remains a leading cause of death for adolescent girls and young women (AGYW) in sub-Saharan Africa. This population has a high incidence of HIV and other comorbidities, such as experiencing violence, and low antiretroviral therapy (ART) adherence. To reach global HIV goals, data are needed on the specific adherence barriers for AGYW living with HIV, so interventions can be targeted effectively. METHODS: Cross-sectional data were collected at urban and rural health facilities in and around Kisumu County, western Kenya, from January to June 2022, from AGYW 15-24 years of age who were living with HIV. Surveys included questions on intimate partner violence, mental health issues, food security, and orphanhood. Adherence was categorized using viral load testing where available and the Center for Adherence Support Evaluation (CASE) adherence index otherwise. Logistic regression was used to assess associations between potential explanatory variables and adherence. FINDINGS: In total, 309 AGYW participated. AGYW with experiences of emotional violence (Odds Ratio [OR] = 1.94, 95% Confidence Interval [CI] = 1.03-3.66), moderate or severe depression (OR = 3.19, 95% CI = 1.47-6.94), and/or substance use (OR = 2.71, 95% CI = 1.24-5.92) had significantly higher odds of poor adherence when compared to AGYW without these respective experiences. Physical and sexual violence, food insecurity, and orphanhood were not associated with poor adherence in this cohort. INTERPRETATION: Elucidating the risk factors associated with poor adherence among AGYW living with HIV allows us to identify potential targets for future interventions to improve ART adherence and HIV care outcomes. Mental health and violence prevention interventions, including combination interventions, may prove to be promising approaches.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Delitos Sexuales / Infecciones por VIH Límite: Adolescent / Female / Humans País/Región como asunto: Africa Idioma: En Revista: Int J Environ Res Public Health Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Delitos Sexuales / Infecciones por VIH Límite: Adolescent / Female / Humans País/Región como asunto: Africa Idioma: En Revista: Int J Environ Res Public Health Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza