Environmental interventions reduced repetitive behavior in a mouse model.
Physiol Behav
; 273: 114386, 2024 Jan 01.
Article
en En
| MEDLINE
| ID: mdl-37884109
ABSTRACT
Repetitive motor behaviors are associated with several neurodevelopmental disorders including autism spectrum disorder. Non-invasive environmental interventions that can ameliorate repetitive behavior and be introduced in early development could benefit many. In Experiment 1, we characterized the development of repetitive circling in mice reared in standard and enriched environments. Environmental enrichment was associated with reduced repetitive behavior. In Experiment 2, two weekly injections of an A2A adenosine receptor agonist reduced repetitive behavior in mice fed a ketogenic diet. Together, these two approaches modified the environment and reduced repetitive behavior with potential implications for increased functioning of the indirect basal ganglia pathway.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Dieta Cetogénica
/
Trastorno del Espectro Autista
Límite:
Animals
Idioma:
En
Revista:
Physiol Behav
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Estados Unidos