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A novel TRIM22 gene polymorphism promotes the response to PegIFNα therapy through cytokine-cytokine receptor interaction signaling pathway in chronic hepatitis B.
Wang, Long; Lin, Ni; Zhang, Yanfang; Guo, Shaoying; Liu, Can; Lin, Caorui; Zeng, Yongbin; Wu, Wennan; Guo, Jianhui; Zhu, Chenggong; Zhan, Fuguo; Ou, Qishui; Xun, Zhen.
Afiliación
  • Wang L; Department of Laboratory Medicine, Fujian Key Laboratory of Laboratory Medicine, Gene Diagnosis Research Center, Fujian Clinical Research Center for Clinical Immunology Laboratory Test, The First Affiliated Hospital, Fujian Medical University , Fuzhou, Fujian, China.
  • Lin N; The First Clinical College, Fujian Medical University , Fuzhou, Fujian, China.
  • Zhang Y; The First Clinical College, Fujian Medical University , Fuzhou, Fujian, China.
  • Guo S; Department of Laboratory Medicine, Fujian Key Laboratory of Laboratory Medicine, Gene Diagnosis Research Center, Fujian Clinical Research Center for Clinical Immunology Laboratory Test, The First Affiliated Hospital, Fujian Medical University , Fuzhou, Fujian, China.
  • Liu C; The First Clinical College, Fujian Medical University , Fuzhou, Fujian, China.
  • Lin C; The First Clinical College, Fujian Medical University , Fuzhou, Fujian, China.
  • Zeng Y; Department of Laboratory Medicine, Fujian Key Laboratory of Laboratory Medicine, Gene Diagnosis Research Center, Fujian Clinical Research Center for Clinical Immunology Laboratory Test, The First Affiliated Hospital, Fujian Medical University , Fuzhou, Fujian, China.
  • Wu W; The First Clinical College, Fujian Medical University , Fuzhou, Fujian, China.
  • Guo J; Department of Laboratory Medicine, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University , Fuzhou, Fujian, China.
  • Zhu C; Department of Laboratory Medicine, Fujian Key Laboratory of Laboratory Medicine, Gene Diagnosis Research Center, Fujian Clinical Research Center for Clinical Immunology Laboratory Test, The First Affiliated Hospital, Fujian Medical University , Fuzhou, Fujian, China.
  • Zhan F; Department of Laboratory Medicine, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University , Fuzhou, Fujian, China.
  • Ou Q; Department of Laboratory Medicine, Fujian Key Laboratory of Laboratory Medicine, Gene Diagnosis Research Center, Fujian Clinical Research Center for Clinical Immunology Laboratory Test, The First Affiliated Hospital, Fujian Medical University , Fuzhou, Fujian, China.
  • Xun Z; Department of Laboratory Medicine, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University , Fuzhou, Fujian, China.
Microbiol Spectr ; 11(6): e0224723, 2023 Dec 12.
Article en En | MEDLINE | ID: mdl-37882560
IMPORTANCE: Pegylated interferon alfa (PegIFNα) has limited efficacy in the treatment of chronic hepatitis B (CHB). Although many biomarkers related to hepatitis B virus (HBV) have been proposed to stratify patients, the response rate to PegIFNα is still unsatisfactory. Herein, our data suggest that the single-nucleotide polymorphism (SNP) rs10838543 in TRIM22 potentiates a positive clinical response to PegIFNα treatment in patients with hepatitis B e antigen-positive CHB by increasing the levels of IFNL1, CCL3, and CCL5. These observations can help guide treatment decisions for patients with CHB to improve the response rate to PegIFNα.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Interferón-alfa / Hepatitis B Crónica / Proteínas de Motivos Tripartitos Límite: Humans Idioma: En Revista: Microbiol Spectr Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Interferón-alfa / Hepatitis B Crónica / Proteínas de Motivos Tripartitos Límite: Humans Idioma: En Revista: Microbiol Spectr Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos