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Respiratory allergy symptoms and cytokine profiles in the presence of anti-Ascaris antibody in Giardia lamblia-infected children.
Fontenele, Ana Lúcia Arruda; de Oliveira Nóbrega, Cassia Giselle; do Nascimento, Wheverton Ricardo Correia; Santos, Patrícia d'Emery Alves; de Lorena, Virginia Maria Barros; Peixoto, Décio Medeiros; de Azevedo Albuquerque, Mônica Camelo Pessôa; Solé, Dirceu; Costa, Vláudia Maria Assis; Sarinho, Emanuel Sávio Cavalcanti; de Souza, Valdenia Maria Oliveira.
Afiliación
  • Fontenele ALA; Setor de Imunologia, Laboratório de Imunopatologia Keizo Asami, Universidade Federal de Pernambuco, Recife, Brazil.
  • de Oliveira Nóbrega CG; Setor de Imunologia, Laboratório de Imunopatologia Keizo Asami, Universidade Federal de Pernambuco, Recife, Brazil.
  • do Nascimento WRC; Departamento de Medicina Tropical, Universidade Federal de Pernambuco, Recife, Brazil.
  • Santos PDA; Setor de Imunologia, Laboratório de Imunopatologia Keizo Asami, Universidade Federal de Pernambuco, Recife, Brazil.
  • de Lorena VMB; Departamento de Imunologia, Instituto Aggeu Magalhães, Fundação Oswaldo Cruz, Recife, Brazil.
  • Peixoto DM; Centro de Pesquisa em Alergia e Imunologia Clínica, Hospital das Clínicas, Universidade Federal de Pernambuco, Recife, Brazil.
  • de Azevedo Albuquerque MCP; Departamento de Medicina Tropical, Universidade Federal de Pernambuco, Recife, Brazil.
  • Solé D; Divisão de Alergia, Imunologia Clínica e Reumatologia, Departamento de Pediatria da, Universidade Federal de São Paulo, São Paulo, Brazil.
  • Costa VMA; Departamento de Medicina Tropical, Universidade Federal de Pernambuco, Recife, Brazil.
  • Sarinho ESC; Centro de Pesquisa em Alergia e Imunologia Clínica, Hospital das Clínicas, Universidade Federal de Pernambuco, Recife, Brazil.
  • de Souza VMO; Setor de Imunologia, Laboratório de Imunopatologia Keizo Asami, Universidade Federal de Pernambuco, Recife, Brazil. valdenia.souza@ufpe.br.
Parasitol Res ; 122(12): 3147-3158, 2023 Dec.
Article en En | MEDLINE | ID: mdl-37875615
Anti-Ascaris lumbricoides (Asc) IgE and IgG can immunomodulate the allergy; however, the influence of these isotypes has not been investigated in the giardiasis and allergy. Therefore, the frequency of respiratory allergy (RA) symptoms in Giardia lamblia-infected children, with or without anti-Asc IgE, IgG1, or IgG4 and Th1, Th2/Treg, and Th17 cytokine production, was evaluated. We performed a case-control study with children aged 2-10 years old selected by questionnaire and stool exams to form the groups: infected or uninfected with RA (G-RA, n = 55; nG-RA, n = 43); infected and uninfected without RA (G-nRA, n = 59; nG-nRA, n = 54). We performed blood leukocyte counts and in vitro culture. Cytokine levels in the supernatants (CBA), serum total IgE and anti-Asc IgE (ImmunoCAP), IgG1, IgG4, and total IgA (ELISA) were measured. Infection was not associated with allergy. Infected children showed increased levels of anti-Asc IgG1, IL-2, IFN-γ, IL-4, and IL-10. There was a lower frequency of allergy-related symptoms in anti-Asc IgG1-positive children than IgG1-negative (OR = 0.38; CI = 0.17-0.90, p = 0.027) and few eosinophils in G-RA than in G-nRA and more in G-nRA than in nG-nRA, whereas TNF-α levels were higher in the G-RA than in the nG-nRA group. For infected and positive anti-Asc IgG1, there was higher TNF-α and IL-10 production than G/-IgG1. IL-10 levels were lower in nG/ + IgG1 than in infected or non-infected, and both were negative for anti-Asc IgG1. Th1/Th2/IL-10 profiles were stimulated in the infected patients, and in those with circulating anti-Asc IgG1, the TNF-α production was strengthened with a lower risk for respiratory allergy symptoms.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Giardia lamblia / Hipersensibilidad Límite: Animals / Child / Child, preschool / Humans Idioma: En Revista: Parasitol Res Asunto de la revista: PARASITOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Alemania
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Giardia lamblia / Hipersensibilidad Límite: Animals / Child / Child, preschool / Humans Idioma: En Revista: Parasitol Res Asunto de la revista: PARASITOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Alemania