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The clinical use of polygenic risk scores.
Terkelsen, Thorkild; Hansen, Thomas Folkmann; Herlin, Morten Krogh; Djursby, Malene; Nyegaard, Mette; Pedersen, Inge Søkilde; Lildballe, Dorte Launholt; Færgeman, Søren Lejsted; Sunde, Lone; Hauberg, Mads Engel.
Afiliación
  • Terkelsen T; Klinisk Genetisk Afdeling, Aarhus Universitetshospital.
  • Hansen TF; Brunak Group, Københavns Universitet.
  • Herlin MK; Klinisk Genetisk Afdeling, Aarhus Universitetshospital.
  • Djursby M; Klinisk Genetisk Afdeling, Københavns Universitetshospital - Rigshospitalet.
  • Nyegaard M; Institut for Medicin og Sundhedsteknologi, Aalborg Universitet.
  • Pedersen IS; Afsnit for Molekylær Diagnostik, Aalborg Universitetshospital.
  • Lildballe DL; Molekylær Medicinsk Afdeling, Aarhus Universitetshospital.
  • Færgeman SL; Klinisk Genetisk Afdeling, Aarhus Universitetshospital.
  • Sunde L; Klinisk Genetisk Afdeling, Aalborg Universitetshospital.
  • Hauberg ME; Hormon- og Knoglesygdomme, Aarhus Universitetshospital.
Ugeskr Laeger ; 185(39)2023 09 25.
Article en Da | MEDLINE | ID: mdl-37873989
Polygenic risk scores (PRS) identify at-risk individuals for many common diseases. A discussion of strengths and limitations is carried out in this review. PRS complement traditional genetic testing and have shown utility in establishing a proper diagnosis and guiding primary and secondary prevention. Some individuals with high PRS have risks similar to those with monogenic predisposition. Limitations include potential misinterpretations, problems with application across ancestries, and limited usefulness in low-heritability traits. Despite its shortcomings PRS are predicted to play major roles in the future of personal medicine and genetic testing.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pruebas Genéticas / Medicina Límite: Humans Idioma: Da Revista: Ugeskr Laeger Año: 2023 Tipo del documento: Article Pais de publicación: Dinamarca
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pruebas Genéticas / Medicina Límite: Humans Idioma: Da Revista: Ugeskr Laeger Año: 2023 Tipo del documento: Article Pais de publicación: Dinamarca