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Ventral hippocampus neurons encode meal-related memory.
Décarie-Spain, Léa; Gu, Cindy; Lauer, Logan Tierno; Subramanian, Keshav S; Chehimi, Samar N; Kao, Alicia E; Deng, Iris; Bashaw, Alexander G; Klug, Molly E; Galbokke, Ashyah Hewage; Donohue, Kristen N; Yang, Mingxin; de Lartigue, Guillaume; Myers, Kevin P; Crist, Richard C; Reiner, Benjamin C; Hayes, Matthew R; Kanoski, Scott E.
Afiliación
  • Décarie-Spain L; Human & Evolutionary Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, California, United States.
  • Gu C; Human & Evolutionary Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, California, United States.
  • Lauer LT; Human & Evolutionary Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, California, United States.
  • Subramanian KS; Neuroscience Graduate Program, University of Southern California, Los Angeles, California, United States.
  • Chehimi SN; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States.
  • Kao AE; Human & Evolutionary Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, California, United States.
  • Deng I; Human & Evolutionary Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, California, United States.
  • Bashaw AG; Neuroscience Graduate Program, University of Southern California, Los Angeles, California, United States.
  • Klug ME; Human & Evolutionary Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, California, United States.
  • Galbokke AH; Human & Evolutionary Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, California, United States.
  • Donohue KN; Human & Evolutionary Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, California, United States.
  • Yang M; Monell Chemical Sense Center, Philadelphia, Pennsylvania, United States.
  • de Lartigue G; Monell Chemical Sense Center, Philadelphia, Pennsylvania, United States.
  • Myers KP; Bucknell University, Lewisburg, Philadelphia, Pennsylvania, United States.
  • Crist RC; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States.
  • Reiner BC; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States.
  • Hayes MR; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States.
  • Kanoski SE; Human & Evolutionary Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, California, United States.
bioRxiv ; 2023 Oct 10.
Article en En | MEDLINE | ID: mdl-37873229
The ability to encode and retrieve meal-related information is critical to efficiently guide energy acquisition and consumption, yet the underlying neural processes remain elusive. Here we reveal that ventral hippocampus (HPCv) neuronal activity dynamically elevates during meal consumption and this response is highly predictive of subsequent performance in a foraging-related spatial memory task. Targeted recombination-mediated ablation of HPCv meal-responsive neurons impairs foraging-related spatial memory without influencing food motivation, anxiety-like behavior, or escape-mediated spatial memory. These HPCv meal-responsive neurons project to the lateral hypothalamic area (LHA) and single-nucleus RNA sequencing and in situ hybridization analyses indicate they are enriched in serotonin 2a receptors (5HT2aR). Either chemogenetic silencing of HPCv-to-LHA projections or intra-HPCv 5HT2aR antagonist yielded foraging-related spatial memory deficits, as well as alterations in caloric intake and the temporal sequence of spontaneous meal consumption. Collective results identify a population of HPCv neurons that dynamically respond to eating to encode meal-related memories.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: BioRxiv Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: BioRxiv Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos