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A battery-less implantable glucose sensor based on electrical impedance spectroscopy.
Ollmar, Stig; Fernandez Schrunder, Alejandro; Birgersson, Ulrik; Kristoffersson, Tomas; Rusu, Ana; Thorsson, Elina; Hedenqvist, Patricia; Manell, Elin; Rydén, Anneli; Jensen-Waern, Marianne; Rodriguez, Saul.
Afiliación
  • Ollmar S; Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm, Sweden.
  • Fernandez Schrunder A; School of Electrical Engineering and Computer Science, KTH Royal Institute of Technology, 16440, Kista, Sweden.
  • Birgersson U; Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm, Sweden.
  • Kristoffersson T; Prevas AB, Stockholm, Sweden.
  • Rusu A; School of Electrical Engineering and Computer Science, KTH Royal Institute of Technology, 16440, Kista, Sweden.
  • Thorsson E; Pathology Unit, Department of Biomedical Science and Veterinary Public Health, Swedish University of Agricultural Sciences, Uppsala, Sweden.
  • Hedenqvist P; Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.
  • Manell E; Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.
  • Rydén A; Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.
  • Jensen-Waern M; Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.
  • Rodriguez S; School of Electrical Engineering and Computer Science, KTH Royal Institute of Technology, 16440, Kista, Sweden. saul@kth.se.
Sci Rep ; 13(1): 18122, 2023 10 23.
Article en En | MEDLINE | ID: mdl-37872272
The ability to perform accurate continuous glucose monitoring without blood sampling has revolutionised the management of diabetes. Newer methods that can allow measurements during longer periods are necessary to substantially improve patients' quality of life. This paper presents an alternative method for glucose monitoring which is based on electrical impedance spectroscopy. A battery-less implantable bioimpedance spectroscope was designed, built, and used in an in vivo study on pigs. After a recovery period of 14 days post surgery, a total of 236 subcutaneous bioimpedance measurements obtained from intravenous glucose tolerance tests, with glucose concentration ranges between 77.4 and 523.8 mg/dL, were analyzed. The results show that glucose concentrations estimated by subcutaneous bioimpedance measurements correlate very well to the blood glucose reference values. The pigs were clinically healthy throughout the study, and the postmortem examinations revealed no signs of adverse effects related to the sensor. The implantation of the sensor requires minor surgery. The implant, being externally powered, could in principle last indefinitely. These encouraging results demonstrate the potential of the bioimpedance method to be used in future continuous glucose monitoring systems.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glucemia / Diabetes Mellitus Tipo 1 Límite: Animals / Humans Idioma: En Revista: Sci Rep Año: 2023 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Reino Unido
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glucemia / Diabetes Mellitus Tipo 1 Límite: Animals / Humans Idioma: En Revista: Sci Rep Año: 2023 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Reino Unido