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Glycemic control and prescription profiles in internal medicine inpatients: The role of frailty.
Arévalo Lorido, Jose Carlos; Carretero Gomez, Juana; Vazquez Rodriguez, Patricia; Gómez Huelgas, Ricardo; Marín Silvente, Carmen; Sánchez Lora, Fernando Javier; Isaba Ares, Elena; Pardo I Pelegrín, Anna; Pérez Hernández, Onán; Ena, Javier.
Afiliación
  • Arévalo Lorido JC; Internal Medicine Service, Hospital Universitario de Badajoz, Avda de Elvas, s/n, Badajoz 06080, Spain.
  • Carretero Gomez J; Internal Medicine Service, Hospital Universitario de Badajoz, Avda de Elvas, s/n, Badajoz 06080, Spain. Electronic address: juana.carretero@salud-juntaex.es.
  • Vazquez Rodriguez P; Internal Medicine Service, Hospital Universitario de A Coruña, As Xubias, 84, A Coruña 15006, Spain.
  • Gómez Huelgas R; Internal Medicine Service, Hospital Universitario de Málaga, Av. de Carlos Haya, 84, Málaga 29010, Spain.
  • Marín Silvente C; Internal Medicine Service, Hospital General Universitario Morales Meseguer, Av. Marqués de Los Vélez, s/n, Murcia 30008, Spain.
  • Sánchez Lora FJ; Internal Medicine Service, Hospital Virgen de la Victoria, Campus de Teatinos, S/N, Málaga 29010, Spain.
  • Isaba Ares E; Internal Medicine Service, Hospital Universitario de Móstoles, C. Dr. Luis Montes, s/n, Móstoles, Madrid 28935, Spain.
  • Pardo I Pelegrín A; Internal Medicine Service, Hospital Sant Rafael, Pg. de la Vall d'Hebron, 107, Barcelona 08035, Spain.
  • Pérez Hernández O; Internal medicine Service, Hospital Universitario Nuestra Señora de la Candelaria, Ctra. Gral. del Rosario, 145, Santa Cruz de Tenerife 38010, Spain.
  • Ena J; Internal Medicine Service, Hospital Marina Baixa, Av. Alcalde En Jaume Botella Mayor, 7, Villajoyosa, Alicante 03570, Spain.
Eur J Intern Med ; 121: 103-108, 2024 Mar.
Article en En | MEDLINE | ID: mdl-37872036
AIM: This work aims to characterize the clinical profile of individuals with frailty syndrome, diabetes mellitus (DM), and hyperglycemia during hospitalization in regard to glycemic control and treatment regimen. METHODS: This cross-sectional multicentric study included patients with DM or hyperglycemia at admission. Demographic data, blood glucose values, treatment administered during hospitalization, and treatment indicated at discharge were analyzed. The sample was divided into three groups according to score on a frailty questionnaire. Generalized additive models were used to describe the relationship between either glycemic variability (GV) or minimum capillary blood glucose and hypoglycemia. Models were adjusted for age, comorbidity, and sarcopenia. RESULTS: A total of 1,137 patients were analyzed. Patients with frailty syndrome had more comorbidity and sarcopenia, worse renal function, and lower albumin and lymphocyte levels. A GV between 21% and 60% was related to a higher probability of hypoglycemia, especially in patients with frailty. Regarding minimum capillary blood glucose, patients with frailty had the highest probability of hypoglycemia. This probability remained significant even in the group with frailty in which, with a reference value of 200 mg/dl, the adjusted odds ratio of a minimum capillary blood glucose of 151 mg/dL was 1.08 (95% confidence interval (1.12-1.05)). Baseline treatments showed a significant predominance of insulin use in the frailest groups. CONCLUSIONS: Patients with frailty had more sarcopenia and undernourishment. These patients were managed in a similar manner during hospitalization to patients without frailty, despite their higher risk of hypoglycemia according to GV or minimum capillary blood glucose levels.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus / Sarcopenia / Fragilidad / Hiperglucemia / Hipoglucemia Límite: Aged / Humans Idioma: En Revista: Eur J Intern Med Asunto de la revista: MEDICINA INTERNA Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus / Sarcopenia / Fragilidad / Hiperglucemia / Hipoglucemia Límite: Aged / Humans Idioma: En Revista: Eur J Intern Med Asunto de la revista: MEDICINA INTERNA Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Países Bajos