Modeling the protein binding non-linearity in population pharmacokinetic model of valproic acid in children with epilepsy: a systematic evaluation study.

Zhang, Lina; Liu, Maochang; Qin, Weiwei; Shi, Dandan; Mao, Junjun; Li, Zeyun

Zhang, Lina; Liu, Maochang; Qin, Weiwei; Shi, Dandan; Mao, Junjun; Li, Zeyun.

Afiliación

Zhang L; Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Liu M; Department of Pharmacy, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Qin W; Department of Pharmacy, Huashan Hospital, Fudan University, Shanghai, China.
Shi D; Department of Pediatrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Mao J; Department of Pharmacy, Huashan Hospital, Fudan University, Shanghai, China.
Li Z; Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Front Pharmacol ; 14: 1228641, 2023.

Article en En | MEDLINE | ID: mdl-37869748

Palabras clave

external evaluation; pediatric epilepsy; population pharmacokinetics; protein-binding saturation; therapeutic drug monitoring; valproic acid

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Pharmacol Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza

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