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Methemoglobinemia in the Setting of G6PD Deficiency and SARS-CoV-2 Infection.
Azizbayeva, Rinata; Drennen, Zachary; Solanki, Risha; Keshava, Vinay E; Bhagavatula, Rama; Sareen, Meera; Jiwani, Rahim A; Samhouri, Yazan.
Afiliación
  • Azizbayeva R; Department of Family Medicine, Allegheny Health Network, Pittsburgh, PA, USA.
  • Drennen Z; Department of Anesthesiology, Allegheny Health Network, Pittsburgh, PA, USA.
  • Solanki R; North Allegheny Senior High School, 1749 Stevensan Dr, Sewickley, PA, 15143, USA.
  • Keshava VE; Department of Medical Oncology and Hematology, Allegheny Health Network Cancer Institute, Pittsburgh, PA, USA.
  • Bhagavatula R; Division of Hematology and Cellular Therapy, Allegheny Health Network Cancer Institute, Pittsburgh, PA, USA.
  • Sareen M; Department of Critical Care Medicine, Allegheny Health Network, Pittsburgh, PA, USA.
  • Jiwani RA; Department of Medical Oncology and Hematology, Allegheny Health Network Cancer Institute, Pittsburgh, PA, USA.
  • Samhouri Y; Division of Hematology and Cellular Therapy, Allegheny Health Network Cancer Institute, Pittsburgh, PA, USA.
J Community Hosp Intern Med Perspect ; 13(5): 61-64, 2023.
Article en En | MEDLINE | ID: mdl-37868669
catalyzes the pentose phosphate shunt. It is required to maintain the level of nicotinamide adenine dinucleotide We report a case of a 58 year old African American male patient with Coronavirus Disease-2019 (COVID-19) in the setting of multiple concomitant hematologic disorders, including Glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency) and sickle cell trait. Typically, G6PD deficiency remains clinically silent, and only a minority of patients will show signs of chronic hemolytic anemia. However, all G6PD deficient patients are at risk of non-immune hemolysis after exposure to a variety of infectious pathogens, including COVID-19. Our patient displayed evidence of methemoglobinemia and subsequent tissue anoxia. We review the theories and mechanisms behind the increased risk of complications and severity of illness in the context of COVID-19 and hematologic disorders. These patients may require alternative treatment pathways due to their comorbidities. This case emphasizes the complications that can arise in this setting, and highlights important considerations for patient treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Community Hosp Intern Med Perspect Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Community Hosp Intern Med Perspect Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos