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Stress hormone response to instrumented elective lumbar spine fusion surgery.
Repo, Jussi P; Neva, Marko H; Häkkinen, Keijo; Pekkanen, Liisa; Metso, Saara; Häkkinen, Arja H.
Afiliación
  • Repo JP; Unit of Musculoskeletal Diseases, Department of Orthopaedic, Tampere University Hospital, Tampere, Finland.
  • Neva MH; Unit of Musculoskeletal Diseases, Department of Orthopaedic, Tampere University Hospital, Tampere, Finland.
  • Häkkinen K; Biology of Physical activity, Faculty of Sport and Health Sciences, University of Jyväskylä, Finland.
  • Pekkanen L; Department of orthopedics and traumatology, Hospital Nova, Jyväskylä, Finland.
  • Metso S; Department of Internal Medicine, Tampere University Hospital, Tampere, Finland.
  • Häkkinen AH; Faculty of Medicine and Life Sciences, Tampere University Hospital, Tampere, Finland.
J Orthop Surg (Hong Kong) ; 31(3): 10225536231201910, 2023.
Article en En | MEDLINE | ID: mdl-37864428
PURPOSE: To understand the systemic effect of major spine surgery, we investigated stress, anabolic and catabolic hormonal levels and their association with interleukin 6 (IL-6) in patients undergoing elective lumbar spine fusion surgery. METHODS: Blood samples were collected preoperatively, and at 1, 3, 42, 90 days postoperatively (POD) from 49 patients who underwent elective lumbar spine fusion surgery. RESULTS: Serum concentration of cortisol was below the preoperative value at POD 1 but did not differ from the baseline values thereafter. Adrenocorticotropic hormone (ACTH) decreased at PODs 1 and 3. Testosterone decreased at PODs 1 and 3 in men, and at POD 3 in women. Sex hormone-binding globulin decreased at PODs 1 and 3 in both genders. No changes were observed in free testosterone or growth hormone concentrations. Insulin-like growth factor 1 increased significantly above the preoperative level at PODs 42 and 90 in women, and at POD 42 in men. IL-6 was significantly elevated at PODs 1 and 3. Increases in IL-6 from the preoperative level to POD 1 correlated significantly with decreases of cortisol at POD 1 but not with ACTH. CONCLUSIONS: There were only short-term stress hormonal changes after elective lumbar spine fusion surgery. Cortisol changes after elective lumbar spine surgery are transient and might be partly cytokine induced and non-ACTH driven since there was association between cortisol and IL-6 but not with ACTH and IL-6.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fusión Vertebral / Hidrocortisona Límite: Female / Humans / Male Idioma: En Revista: J Orthop Surg (Hong Kong) Asunto de la revista: ORTOPEDIA Año: 2023 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fusión Vertebral / Hidrocortisona Límite: Female / Humans / Male Idioma: En Revista: J Orthop Surg (Hong Kong) Asunto de la revista: ORTOPEDIA Año: 2023 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Reino Unido