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Cerebrovascular Abnormalities in Adults Born SGA at 12 Years After Growth Hormone Cessation Compared to Controls.
Dorrepaal, Demi Justine; Goedegebuure, Wesley Jim; Smagge, Lucas; van der Steen, Manouk; van der Lugt, Aad; Hokken-Koelega, Anita Charlotte Suzanne.
Afiliación
  • Dorrepaal DJ; Department of Pediatrics, Erasmus Medical Center-Sophia Children's Hospital, 3015 CN Rotterdam, The Netherlands.
  • Goedegebuure WJ; Department of Pediatrics, Erasmus Medical Center-Sophia Children's Hospital, 3015 CN Rotterdam, The Netherlands.
  • Smagge L; Department of Radiology, Erasmus Medical Center, 3015 CN Rotterdam, The Netherlands.
  • van der Steen M; Department of Pediatrics, Erasmus Medical Center-Sophia Children's Hospital, 3015 CN Rotterdam, The Netherlands.
  • van der Lugt A; Department of Radiology, Erasmus Medical Center, 3015 CN Rotterdam, The Netherlands.
  • Hokken-Koelega ACS; Department of Pediatrics, Erasmus Medical Center-Sophia Children's Hospital, 3015 CN Rotterdam, The Netherlands.
J Clin Endocrinol Metab ; 109(3): e1185-e1193, 2024 Feb 20.
Article en En | MEDLINE | ID: mdl-37855389
CONTEXT: Increased cerebrovascular morbidity was reported in adults born small for gestational age (SGA) who were treated with growth hormone (GH) during childhood compared to the general population. However, previous studies did not have an appropriate control group, which is a major limitation. OBJECTIVE: To study cerebrovascular abnormalities (aneurysms, previous intracerebral hemorrhages and microbleeds) using magnetic resonance imaging (MRI) in adults born SGA at 12 years after cessation of childhood GH treatment (SGA-GH) compared to appropriate controls. METHODS: In this single-center, prospective study, brain MRIs were performed between May 2016 and December 2020 on a 3T MRI system. MRI images were scored by 2 neuroradiologists who were blinded to patient groupings. Participants included adults born SGA previously treated with GH and 3 untreated control groups: adults born SGA with persistent short stature (SGA-S), adults born SGA with spontaneous catch-up growth to a normal height (SGA-CU) and adults born appropriate for gestational age with a normal height (AGA). The intervention was long-term GH treatment during childhood and the main outcome measure was cerebrovascular abnormalities. RESULTS: A total of 301 adults were investigated. Aneurysms were found in 6 adults: 3 (3.6%) SGA-GH, 1 (2.9%) SGA-S and 2 (2.2%) AGA adults, without differences between SGA-GH adults and the controls. Previous intracerebral hemorrhages were only found in 2 SGA-S adults (4.8%). Microbleeds were found in 17 adults: 4 (4.3%) SGA-GH, 4 (9.5%) SGA-S, 3 (4.3%) SGA-CU and 6 (6.3%) AGA adults, without differences between SGA-GH adults and the controls. CONCLUSION: Our findings suggest that SGA-GH adults at 12 years after GH cessation have no increased prevalence of cerebrovascular abnormalities compared to appropriate controls. Further research is needed to confirm our findings.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hormona de Crecimiento Humana / Aneurisma Límite: Adult / Female / Humans / Newborn Idioma: En Revista: J Clin Endocrinol Metab Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hormona de Crecimiento Humana / Aneurisma Límite: Adult / Female / Humans / Newborn Idioma: En Revista: J Clin Endocrinol Metab Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos