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The effect of glycine administration on the characteristics of physiological systems in human adults: A systematic review.
Soh, Janjira; Raventhiran, Shivaanishaa; Lee, Jasinda H; Lim, Zi Xiang; Goh, Jorming; Kennedy, Brian K; Maier, Andrea B.
Afiliación
  • Soh J; Centre for Healthy Longevity, National University Health System (NUHS), Singapore, Singapore.
  • Raventhiran S; Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, Singapore.
  • Lee JH; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, Singapore.
  • Lim ZX; Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, Singapore.
  • Goh J; Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, Singapore.
  • Kennedy BK; Centre for Healthy Longevity, National University Health System (NUHS), Singapore, Singapore.
  • Maier AB; Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, Singapore.
Geroscience ; 46(1): 219-239, 2024 Feb.
Article en En | MEDLINE | ID: mdl-37851316
Functional decline of physiological systems during ageing leads to age-related diseases. Dietary glycine increases healthy lifespan in model organisms and might decrease inflammation in humans, suggesting its geroprotective potential. This review summarises the evidence of glycine administration on the characteristics of eleven physiological systems in adult humans. Databases were searched using key search terms: 'glycine', 'adult', 'supplementation'/ 'administration'/ 'ingestion'/ 'treatment'. Glycine was administered to healthy and diseased populations (18 and 34 studies) for up to 14 days and 4 months, respectively. The nervous system demonstrated the most positive effects, including improved psychiatric symptoms from longer-term glycine administration in psychiatric populations. While longer-term glycine administration improved sleep in healthy populations, these studies had small sample sizes with a high risk of bias. Larger and long-term studies with more robust study designs in healthy populations to examine the effects of glycine administration on preventing, delaying or reversing the ageing process are warranted.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estado de Salud / Suplementos Dietéticos / Glicina Tipo de estudio: Systematic_reviews Límite: Humans Idioma: En Revista: Geroscience Año: 2024 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estado de Salud / Suplementos Dietéticos / Glicina Tipo de estudio: Systematic_reviews Límite: Humans Idioma: En Revista: Geroscience Año: 2024 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Suiza