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Eomesodermin expression in CD4+T-cells associated with disease progression in amyotrophic lateral sclerosis.
Chen, Sheng; Huan, Xiao; Xu, Chun-Zuan; Luo, Su-Shan; Zhao, Chong-Bo; Zhong, Hua-Hua; Zheng, Xue-Ying; Qiao, Kai; Dong, Yi; Wang, Ying; Liu, Chang-Yun; Huang, Hua-Pin; Chen, Yan; Zou, Zhang-Yu.
Afiliación
  • Chen S; Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, China.
  • Huan X; Institute of Clinical Neurology, Fujian Medical University, Fuzhou, China.
  • Xu CZ; Huashan Rare Disease Center and Department of Neurology, Huashan Hospital, Shanghai Medical College, National Center for Neurological Disorders, Fudan University, Shanghai, China.
  • Luo SS; Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, China.
  • Zhao CB; Institute of Clinical Neurology, Fujian Medical University, Fuzhou, China.
  • Zhong HH; Huashan Rare Disease Center and Department of Neurology, Huashan Hospital, Shanghai Medical College, National Center for Neurological Disorders, Fudan University, Shanghai, China.
  • Zheng XY; Huashan Rare Disease Center and Department of Neurology, Huashan Hospital, Shanghai Medical College, National Center for Neurological Disorders, Fudan University, Shanghai, China.
  • Qiao K; Huashan Rare Disease Center and Department of Neurology, Huashan Hospital, Shanghai Medical College, National Center for Neurological Disorders, Fudan University, Shanghai, China.
  • Dong Y; Department of Biostatistics, School of Public Health and Key Laboratory of Public Health Safety, Fudan University, Shanghai, China.
  • Wang Y; Huashan Rare Disease Center and Department of Neurology, Huashan Hospital, Shanghai Medical College, National Center for Neurological Disorders, Fudan University, Shanghai, China.
  • Liu CY; Huashan Rare Disease Center and Department of Neurology, Huashan Hospital, Shanghai Medical College, National Center for Neurological Disorders, Fudan University, Shanghai, China.
  • Huang HP; Department of Pharmacy, Fudan University Huashan Hospital, Shanghai, China.
  • Chen Y; Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, China.
  • Zou ZY; Institute of Clinical Neurology, Fujian Medical University, Fuzhou, China.
CNS Neurosci Ther ; 30(4): e14503, 2024 04.
Article en En | MEDLINE | ID: mdl-37850654
AIM: To clarify the role of Eomesodermin (EOMES) to serve as a disease-relevant biomarker and the intracellular molecules underlying the immunophenotype shifting of CD4+T subsets in amyotrophic lateral sclerosis (ALS). METHODS: The derivation and validation cohorts included a total of 148 ALS patients and 101 healthy controls (HCs). Clinical data and peripheral blood were collected. T-cell subsets and the EOMES expression were quantified using multicolor flow cytometry. Serum neurofilament light chain (NFL) was measured. In 1-year longitudinal follow-ups, the ALSFRS-R scores and primary endpoint events were further recorded in the ALS patients of the validation cohort. RESULTS: In the derivation cohort, the CD4+EOMES+T-cell subsets were significantly increased (p < 0.001). EOMES+ subset was positively correlated with increased serum NFL levels in patients with onset longer than 12 months. In the validation cohort, the elevated CD4+EOMES+T-cell proportions and their association with NFL levels were also identified. The longitudinal study revealed that ALS patients with higher EOMES expression were associated with higher progression rates (p = .010) and worse prognosis (p = .003). CONCLUSIONS: We demonstrated that increased CD4+EOMES+T-cell subsets in ALS were associated with disease progression and poor prognosis. Identifying these associations may contribute to a better understanding of the immunopathological mechanism of ALS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esclerosis Amiotrófica Lateral Límite: Humans Idioma: En Revista: CNS Neurosci Ther Asunto de la revista: NEUROLOGIA / TERAPEUTICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esclerosis Amiotrófica Lateral Límite: Humans Idioma: En Revista: CNS Neurosci Ther Asunto de la revista: NEUROLOGIA / TERAPEUTICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido