A cyclic peptide-based PROTAC induces intracellular degradation of palmitoyltransferase and potently decreases PD-L1 expression in human cervical cancer cells.

Shi, Yu-Ying; Dong, Di-Rong; Fan, Gang; Dai, Meng-Yuan; Liu, Miao

Shi, Yu-Ying; Dong, Di-Rong; Fan, Gang; Dai, Meng-Yuan; Liu, Miao.

Afiliación

Shi YY; Department of Gynecological Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Dong DR; Department of Gynecological Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Fan G; Department of Urology, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, China.
Dai MY; Department of Gynecological Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Liu M; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.

Front Immunol ; 14: 1237964, 2023.

Article en En | MEDLINE | ID: mdl-37849747

Asunto(s)

Péptidos Cíclicos; Neoplasias del Cuello Uterino; Femenino; Humanos; Péptidos Cíclicos/farmacología; Antígeno B7-H1/metabolismo; Línea Celular Tumoral; Péptidos/farmacología; Péptidos/química; Transferasas; Disulfuros

Palabras clave

DHHC3; PD-L1; cervical cancer; cyclic peptide PROTAC; immunotherapy

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos Cíclicos / Neoplasias del Cuello Uterino Límite: Female / Humans Idioma: En Revista: Front Immunol Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza

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