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Filoviruses: Scientific Gaps and Prototype Pathogen Recommendation.
Dupuy, Lesley C; Spiropoulou, Christina F; Towner, Jonathan S; Spengler, Jessica R; Sullivan, Nancy J; Montgomery, Joel M.
Afiliación
  • Dupuy LC; Virology Branch, Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
  • Spiropoulou CF; Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Towner JS; Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Spengler JR; Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Sullivan NJ; National Emerging Infectious Diseases Laboratories, Boston University, Boston, Massachusetts, USA.
  • Montgomery JM; Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
J Infect Dis ; 228(Suppl 6): S446-S459, 2023 10 18.
Article en En | MEDLINE | ID: mdl-37849404
Viruses in the family Filoviridae, including the commonly known Ebola (EBOV) and Marburg (MARV) viruses, can cause severe hemorrhagic fever in humans and nonhuman primates. Sporadic outbreaks of filovirus disease occur in sub-Saharan Africa with reported case fatality rates ranging from 25% to 90%. The high mortality and increasing frequency and magnitude of recent outbreaks along with the increased potential for spread from rural to urban areas highlight the importance of pandemic preparedness for these viruses. Despite their designation as high-priority pathogens, numerous scientific gaps exist in critical areas. In this review, these gaps and an assessment of potential prototype pathogen candidates are presented for this important virus family.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Filoviridae / Fiebre Hemorrágica Ebola / Ebolavirus / Marburgvirus Límite: Animals / Humans Idioma: En Revista: J Infect Dis Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Filoviridae / Fiebre Hemorrágica Ebola / Ebolavirus / Marburgvirus Límite: Animals / Humans Idioma: En Revista: J Infect Dis Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos