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New insights in the mechanisms of weight-loss maintenance: Summary from a Pennington symposium.
Flanagan, Emily W; Spann, Redin; Berry, Sarah E; Berthoud, Hans-Rudolf; Broyles, Stephanie; Foster, Gary D; Krakoff, Jonathan; Loos, Ruth J F; Lowe, Michael R; Ostendorf, Danielle M; Powell-Wiley, Tiffany M; Redman, Leanne M; Rosenbaum, Michael; Schauer, Philip R; Seeley, Randy J; Swinburn, Boyd A; Hall, Kevin; Ravussin, Eric.
Afiliación
  • Flanagan EW; Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
  • Spann R; Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
  • Berry SE; Department of Nutritional Sciences, King's College London, London, UK.
  • Berthoud HR; Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
  • Broyles S; Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
  • Foster GD; WW International, New York, New York, USA.
  • Krakoff J; Center for Weight and Eating Disorders, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Loos RJF; Obesity and Diabetes Clinical Research Section, Phoenix Epidemiology & Clinical Research Branch, NIDDK-Phoenix, Phoenix, Arizona, USA.
  • Lowe MR; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Ostendorf DM; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Powell-Wiley TM; Drexel University, Philadelphia, Pennsylvania, USA.
  • Redman LM; Department of Medicine, Anschutz Health and Wellness Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
  • Rosenbaum M; Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
  • Schauer PR; Social Determinants of Obesity and Cardiovascular Risk Laboratory, Cardiovascular Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
  • Seeley RJ; Intramural Research Program, National Institute on Minority Health and Health Disparities, National Institutes of Health, Bethesda, Maryland, USA.
  • Swinburn BA; Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
  • Hall K; Division of Molecular Genetics and Irving Center for Clinical and Translational Research, Columbia University Irving Medical Center, New York, New York, USA.
  • Ravussin E; Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
Obesity (Silver Spring) ; 31(12): 2895-2908, 2023 Dec.
Article en En | MEDLINE | ID: mdl-37845825
Obesity is a chronic disease that affects more than 650 million adults worldwide. Obesity not only is a significant health concern on its own, but predisposes to cardiometabolic comorbidities, including coronary heart disease, dyslipidemia, hypertension, type 2 diabetes, and some cancers. Lifestyle interventions effectively promote weight loss of 5% to 10%, and pharmacological and surgical interventions even more, with some novel approved drugs inducing up to an average of 25% weight loss. Yet, maintaining weight loss over the long-term remains extremely challenging, and subsequent weight gain is typical. The mechanisms underlying weight regain remain to be fully elucidated. The purpose of this Pennington Biomedical Scientific Symposium was to review and highlight the complex interplay between the physiological, behavioral, and environmental systems controlling energy intake and expenditure. Each of these contributions were further discussed in the context of weight-loss maintenance, and systems-level viewpoints were highlighted to interpret gaps in current approaches. The invited speakers built upon the science of obesity and weight loss to collectively propose future research directions that will aid in revealing the complicated mechanisms involved in the weight-reduced state.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 2 Límite: Adult / Humans Idioma: En Revista: Obesity (Silver Spring) Asunto de la revista: CIENCIAS DA NUTRICAO / FISIOLOGIA / METABOLISMO Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 2 Límite: Adult / Humans Idioma: En Revista: Obesity (Silver Spring) Asunto de la revista: CIENCIAS DA NUTRICAO / FISIOLOGIA / METABOLISMO Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos