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Scaling up stem cell production: harnessing the potential of microfluidic devices.
Ding, Lin; Oh, Steve; Shrestha, Jesus; Lam, Alan; Wang, Yaqing; Radfar, Payar; Warkiani, Majid Ebrahimi.
Afiliación
  • Ding L; Smart MCs Pty Ltd, Ultimo, Sydney, 2007, Australia. Electronic address: lin@smartmcs.com.au.
  • Oh S; Stem Cell Group, Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR), Singapore, 138668, Singapore.
  • Shrestha J; School of Biomedical Engineering, University of Technology Sydney, Sydney, NSW 2007, Australia.
  • Lam A; Stem Cell Group, Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR), Singapore, 138668, Singapore.
  • Wang Y; School of Biomedical Engineering, University of Science and Technology of China, Hefei 230026, China; Suzhou Institute for Advanced Research, University of Science and Technology of China, Suzhou 215123, China.
  • Radfar P; Smart MCs Pty Ltd, Ultimo, Sydney, 2007, Australia.
  • Warkiani ME; School of Biomedical Engineering, University of Technology Sydney, Sydney, NSW 2007, Australia.. Electronic address: majid.warkiani@uts.edu.au.
Biotechnol Adv ; 69: 108271, 2023 12.
Article en En | MEDLINE | ID: mdl-37844769
Stem cells are specialised cells characterised by their unique ability to both self-renew and transform into a wide array of specialised cell types. The widespread interest in stem cells for regenerative medicine and cultivated meat has led to a significant demand for these cells in both research and practical applications. Despite the growing need for stem cell manufacturing, the industry faces significant obstacles, including high costs for equipment and maintenance, complicated operation, and low product quality and yield. Microfluidic technology presents a promising solution to the abovementioned challenges. As an innovative approach for manipulating liquids and cells within microchannels, microfluidics offers a plethora of advantages at an industrial scale. These benefits encompass low setup costs, ease of operation and multiplexing, minimal energy consumption, and the added advantage of being labour-free. This review presents a thorough examination of the prominent microfluidic technologies employed in stem cell research and explores their promising applications in the burgeoning stem cell industry. It thoroughly examines how microfluidics can enhance cell harvesting from tissue samples, facilitate mixing and cryopreservation, streamline microcarrier production, and efficiently conduct cell separation, purification, washing, and final cell formulation post-culture.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Microfluídica / Medicina Regenerativa Idioma: En Revista: Biotechnol Adv Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Microfluídica / Medicina Regenerativa Idioma: En Revista: Biotechnol Adv Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido