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Exploring the therapeutic potential of layered double hydroxides and transition metal dichalcogenides through the convergence of rheumatology and nanotechnology using generative adversarial network.
Lin, Suxian; Chen, Weiwei; Alqahtani, Mohammed S; Elkamchouchi, Dalia H; Ge, Yisu; Lu, Yanjie; Zhang, Guodao; Wang, Mudan.
Afiliación
  • Lin S; Department of Rheumatology, Wenzhou People's Hospital, Wenzhou, 325000, China.
  • Chen W; Department of Rheumatology, Wenzhou People's Hospital, Wenzhou, 325000, China.
  • Alqahtani MS; Radiological Sciences Department, College of Applied Medical Sciences, King Khalid University, Abha 61421, Saudi Arabia; BioImaging Unit, Space Research Centre, Michael Atiyah Building, University of Leicester, Leicester, LE1 7RH, U.K.
  • Elkamchouchi DH; Department of Information Technology, College of Computer and Information Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.
  • Ge Y; College of Computer Science and Artificial Intelligence, Wenzhou University, Wenzhou 325100, China.
  • Lu Y; Department of Digital Media Technology, Hangzhou Dianzi University, Hangzhou 310018, China.
  • Zhang G; Department of Digital Media Technology, Hangzhou Dianzi University, Hangzhou 310018, China. Electronic address: guodaozhang@hdu.edu.cn.
  • Wang M; Department of Nephrology, Wenzhou People's Hospital, Wenzhou, 325000, China. Electronic address: 43138231@qq.com.
Environ Res ; 241: 117262, 2024 Jan 15.
Article en En | MEDLINE | ID: mdl-37839531
Two-dimensional Layered double hydroxides (LDHs) are highly used in the biomedical domain due to their biocompatibility, biodegradability, controlled drug loading and release capabilities, and improved cellular permeability. The interaction of LDHs with biological systems could facilitate targeted drug delivery and make them an attractive option for various biomedical applications. Rheumatoid Arthritis (RA) requires targeted drug delivery for optimum therapeutic outcomes. In this study, stacked double hydroxide nanocomposites with dextran sulphate modification (LDH-DS) were developed while exhibiting both targeting and pH-sensitivity for rheumatological conditions. This research examines the loading, release kinetics, and efficiency of the therapeutics of interest in the LDH-based drug delivery system. The mean size of LDH-DS particles (300.1 ± 8.12 nm) is -12.11 ± 0.4 mV. The encapsulation efficiency was 48.52%, and the loading efficacy was 16.81%. In vitro release tests indicate that the drug's discharge is modified more rapidly in PBS at pH 5.4 compared to pH 5.6, which later reached 7.3, showing the case sensitivity to pH. A generative adversarial network (GAN) is used to analyze the drug delivery system in rheumatology. The GAN model achieved high accuracy and classification rates of 99.3% and 99.0%, respectively, and a validity of 99.5%. The second and third administrations resulted in a significant change with p-values of 0.001 and 0.05, respectively. This investigation unequivocally demonstrated that LDH functions as a biocompatible drug delivery matrix, significantly improving delivery effectiveness.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reumatología / Nanocompuestos Idioma: En Revista: Environ Res Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reumatología / Nanocompuestos Idioma: En Revista: Environ Res Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos