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"Soap bubble" sign as an imaging marker for posterior fossa ependymoma Group B.
Jin, Ying; Cheng, Dan; Duan, Yunyun; Zhuo, Zhizheng; Weng, Jinyuan; Zhang, Chengzhou; Zhu, Mingwang; Liu, Xing; Du, Jiang; Hua, Tiantian; Li, Hongfang; Haller, Sven; Barkhof, Frederik; Liu, Yaou.
Afiliación
  • Jin Y; Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
  • Cheng D; Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
  • Duan Y; Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
  • Zhuo Z; Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
  • Weng J; Department of Medical Imaging Product, Neusoft, Group Ltd., Shenyang, 110179, China.
  • Zhang C; Department of Radiology, Yantai Yuhuangding Hospital, Yantai, 264000, Shandong, China.
  • Zhu M; Department of Radiology, Sanbo Brain Hospital, Capital Medical University, Beijing, 100070, China.
  • Liu X; Department of Pathology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
  • Du J; Department of Pathology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
  • Hua T; Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
  • Li H; Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
  • Haller S; Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
  • Barkhof F; CIMC-Centre d'Imagerie Médicale de Cornavin, Geneva, Switzerland.
  • Liu Y; Department of Surgical Sciences, Radiology, Uppsala University, Uppsala, Sweden.
Neuroradiology ; 65(12): 1707-1714, 2023 Dec.
Article en En | MEDLINE | ID: mdl-37837480
PURPOSE: To investigate the predictive value of the "soap bubble" sign on molecular subtypes (Group A [PFA] and Group B [PFB]) of posterior fossa ependymomas (PF-EPNs). METHODS: MRI scans of 227 PF-EPNs (internal retrospective discovery set) were evaluated by two independent neuroradiologists to assess the "soap bubble" sign, which was defined as clusters of cysts of various sizes that look like "soap bubbles" on T2-weighted images. Two independent cohorts (external validation set [n = 31] and prospective validation set [n = 27]) were collected to validate the "soap bubble" sign. RESULTS: Across three datasets, the "soap bubble" sign was observed in 21 PFB cases (7.4% [21/285] of PF-EPNs and 12.9% [21/163] of PFB); none in PFA. Analysis of the internal retrospective discovery set demonstrated substantial interrater agreement (1st Rating: κ = 0.71 [0.53-0.90], 2nd Rating: κ = 0.83 [0.68-0.98]) and intrarater agreement (Rater 1: κ = 0.73 [0.55-0.91], Rater 2: κ = 0.74 [0.55-0.92]) for the "soap bubble" sign; all 13 cases positive for the "soap bubble" sign were PFB (p = 0.002; positive predictive value [PPV] = 100%, negative predictive value [NPV] = 44%, sensitivity = 10%, specificity = 100%). The findings from the external validation set and the prospective validation set were similar, all cases positive for the "soap bubble" sign were PFB (p < 0.001; PPV = 100%). CONCLUSION: The "soap bubble" sign represents a highly specific imaging marker for the PFB molecular subtype of PF-EPNs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ependimoma Límite: Humans Idioma: En Revista: Neuroradiology Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ependimoma Límite: Humans Idioma: En Revista: Neuroradiology Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania