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Therapeutic Potential of Natural Products in the Treatment of Schistosomiasis.
Azevedo, Carine Machado; Meira, Cássio Santana; da Silva, Jaqueline Wang; Moura, Danielle Maria Nascimento; de Oliveira, Sheilla Andrade; da Costa, Cícero Jádson; Santos, Emanuelle de Souza; Soares, Milena Botelho Pereira.
Afiliación
  • Azevedo CM; Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador 40296-710, Brazil.
  • Meira CS; Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador 40296-710, Brazil.
  • da Silva JW; SENAI Institute of Innovation in Health Advanced Systems (CIMATEC ISI SAS), University Center SENAI/CIMATEC, Salvador 41650-010, Brazil.
  • Moura DMN; SENAI Institute of Innovation in Health Advanced Systems (CIMATEC ISI SAS), University Center SENAI/CIMATEC, Salvador 41650-010, Brazil.
  • de Oliveira SA; Aggeu Magalhães Institute, Oswaldo Cruz Foundation (IAM-FIOCRUZ/PE), Recife 50740-465, Brazil.
  • da Costa CJ; Aggeu Magalhães Institute, Oswaldo Cruz Foundation (IAM-FIOCRUZ/PE), Recife 50740-465, Brazil.
  • Santos ES; Aggeu Magalhães Institute, Oswaldo Cruz Foundation (IAM-FIOCRUZ/PE), Recife 50740-465, Brazil.
  • Soares MBP; SENAI Institute of Innovation in Health Advanced Systems (CIMATEC ISI SAS), University Center SENAI/CIMATEC, Salvador 41650-010, Brazil.
Molecules ; 28(19)2023 Sep 26.
Article en En | MEDLINE | ID: mdl-37836650
It is estimated that 250 million people worldwide are affected by schistosomiasis. Disease transmission is related to the poor sanitation and hygiene habits that affect residents of impoverished regions in tropical and subtropical countries. The main species responsible for causing disease in humans are Schistosoma Mansoni, S. japonicum, and S. haematobium, each with different geographic distributions. Praziquantel is the drug predominantly used to treat this disease, which offers low effectiveness against immature and juvenile parasite forms. In addition, reports of drug resistance prompt the development of novel therapeutic approaches. Natural products represent an important source of new compounds, especially those obtained from plant sources. This review compiles data from several in vitro and in vivo studies evaluating various compounds and essential oils derived from plants with cercaricidal and molluscicidal activities against both juvenile and adult forms of the parasite. Finally, this review provides an important discussion on recent advances in molecular and computational tools deemed fundamental for more rapid and effective screening of new compounds, allowing for the optimization of time and resources.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquistosomiasis / Productos Biológicos / Antihelmínticos Límite: Animals / Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquistosomiasis / Productos Biológicos / Antihelmínticos Límite: Animals / Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza