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Nutritional Status Indices and Monoclonal Gammopathy of Undetermined Significance Risk in the Elderly Population: Findings from the National Health and Nutrition Examination Survey.
Li, Linfeng; Wu, Mengrui; Yu, Zhengyu; Niu, Ting.
Afiliación
  • Li L; Department of Hematology, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Wu M; Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE and State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University and Collaborative Innovation Center, Chengdu 610041, China.
  • Yu Z; Department of Hematology, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Niu T; Department of Hematology, West China Hospital, Sichuan University, Chengdu 610041, China.
Nutrients ; 15(19)2023 Sep 29.
Article en En | MEDLINE | ID: mdl-37836494
OBJECTIVE: Although several studies have found dietary intake is related to multiple myeloma (MM) and its precursor status risks, the role of one's nutritional status has been ignored and its role in plasma cell neoplasm development is still unclear. This study aimed to explore the relationship between various clinical indices of nutritional status and the risk of monoclonal gammopathy of undetermined significance (MGUS) in the population. METHODS: We selected 9520 participants from the NHANES III and NHANES 1999-2004 studies. Controlling nutritional status index (CONUT), prognostic nutritional index (PNI), geriatric nutritional risk index (GNRI) and body mass index (BMI) were calculated as indices of nutritional status of the participants. Associations between nutritional indices and MGUS were investigated using multiple logistic regression, subgroup analysis, and an RCS model. RESULTS: In our study, 266 participants had MGUS, with a prevalence of 2.79%. This study found that CONUT and PNI identified populations with poor nutritional status and had a significant positive correlation with the risk of MGUS. In multivariate logistic regression, compared with the lower CONUT score (<3) group, the OR for the group with higher scores (≥3) was 1.805 (95%CI: 1.271, 2.564). Compared with the lowest quartile group, the highest quartile PNI score group had an OR of 0.509 (95%CI: 0.290, 0.896). GNRI had no significant correlation with the risk of MGUS, with an OR of 0.737 (95%CI: 0.443, 1.227). CONCLUSION: This study found that older adults with CONUT and PNI scores indicating poorer nutrition had a higher risk of MGUS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Gammopatía Monoclonal de Relevancia Indeterminada / Desnutrición / Mieloma Múltiple Límite: Aged / Humans Idioma: En Revista: Nutrients Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Gammopatía Monoclonal de Relevancia Indeterminada / Desnutrición / Mieloma Múltiple Límite: Aged / Humans Idioma: En Revista: Nutrients Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza