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A Novel Mouse Model of Intrahepatic Cholangiocarcinoma Induced by Azoxymethane.
Shirakami, Yohei; Kato, Junichi; Ohnishi, Masaya; Taguchi, Daisuke; Maeda, Toshihide; Ideta, Takayasu; Kubota, Masaya; Sakai, Hiroyasu; Tomita, Hiroyuki; Tanaka, Takuji; Shimizu, Masahito.
Afiliación
  • Shirakami Y; Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.
  • Kato J; Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.
  • Ohnishi M; Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.
  • Taguchi D; Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.
  • Maeda T; Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.
  • Ideta T; Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.
  • Kubota M; Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.
  • Sakai H; Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.
  • Tomita H; Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.
  • Tanaka T; Department of Pathological Diagnosis, Gifu Municipal Hospital, Gifu 500-8513, Japan.
  • Shimizu M; Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.
Int J Mol Sci ; 24(19)2023 Sep 26.
Article en En | MEDLINE | ID: mdl-37834032
Cholangiocarcinoma is the second most common primary cancer of the liver and has a poor prognosis. Various animal models, including carcinogen-induced and genetically engineered rodent models, have been established to clarify the mechanisms underlying cholangiocarcinoma development. In the present study, we developed a novel mouse model of malignant lesions in the biliary ducts induced by the administration of the carcinogen azoxymethane to obese C57BLKS/J-db/db mice. A histopathological analysis revealed that the biliary tract lesions in the liver appeared to be an intrahepatic cholangiocarcinoma with higher tumor incidence, shorter experimental duration, and a markedly increased incidence in obese mice. Molecular markers analyzed using a microarray and a qPCR indicated that the cancerous lesions originated from the cholangiocytes and developed in the inflamed livers. These findings indicated that this is a novel mouse model of intrahepatic cholangiocarcinoma in the context of steatohepatitis. This model can be used to provide a better understanding of the pathogenic mechanisms of cholangiocarcinoma and to develop novel therapeutic strategies for this malignancy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de los Conductos Biliares / Colangiocarcinoma Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de los Conductos Biliares / Colangiocarcinoma Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza