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Postnatal methylmercury exposure and neurodevelopmental outcomes at 7 years of age in the Seychelles Child Development Study Nutrition Cohort 2.
Klus, Jonathan K; Thurston, Sally W; Myers, Gary J; Watson, Gene E; Rand, Matthew D; Love, Tanzy M; Yeates, Alison J; Mulhern, Maria S; McSorley, Emeir M; Strain, J J; Shamlaye, Conrad F; van Wijngaarden, Edwin.
Afiliación
  • Klus JK; University of Rochester Medical Center, School of Medicine & Dentistry, Rochester, NY, USA.
  • Thurston SW; University of Rochester Medical Center, School of Medicine & Dentistry, Rochester, NY, USA.
  • Myers GJ; University of Rochester Medical Center, School of Medicine & Dentistry, Rochester, NY, USA.
  • Watson GE; University of Rochester Medical Center, School of Medicine & Dentistry, Rochester, NY, USA.
  • Rand MD; University of Rochester Medical Center, School of Medicine & Dentistry, Rochester, NY, USA.
  • Love TM; University of Rochester Medical Center, School of Medicine & Dentistry, Rochester, NY, USA.
  • Yeates AJ; Nutrition Innovation Centre for Food and Health (NICHE), Ulster University, Coleraine, Northern Ireland, UK.
  • Mulhern MS; Nutrition Innovation Centre for Food and Health (NICHE), Ulster University, Coleraine, Northern Ireland, UK.
  • McSorley EM; Nutrition Innovation Centre for Food and Health (NICHE), Ulster University, Coleraine, Northern Ireland, UK.
  • Strain JJ; Nutrition Innovation Centre for Food and Health (NICHE), Ulster University, Coleraine, Northern Ireland, UK.
  • Shamlaye CF; Ministry of Health, Victoria, Mahé, Republic of Seychelles.
  • van Wijngaarden E; University of Rochester Medical Center, School of Medicine & Dentistry, Rochester, NY, USA. Electronic address: edwin.vanwijngaarden@rochester.edu.
Neurotoxicology ; 99: 115-119, 2023 Dec.
Article en En | MEDLINE | ID: mdl-37832849
BACKGROUND: Consumption of fish yields many nutritional benefits, but also results in exposure to methylmercury (MeHg). The developing brain is known to be particularly susceptible to MeHg toxicity in high doses. However, the potential impact of low-level environmental exposure from fish consumption on children's neurodevelopment remains unclear. METHODS: We investigated postnatal MeHg exposure at 7 years and its association with a battery of 17 neurodevelopmental outcomes in a subset of children (n = 376) from 1535 enrolled mother-child pairs in Nutrition Cohort 2 of the Seychelles Child Development Study (SCDS NC2). Each outcome was modeled in relation to postnatal MeHg exposure using linear regression, adjusting for prenatal MeHg exposure, levels of maternal polyunsaturated fatty acids (PUFA), and several other covariates known to be associated with neurodevelopmental outcomes. RESULTS: Median postnatal MeHg exposure at 7 years was 2.5 ppm, while the median prenatal MeHg exposure was 3.5 ppm. We found no statistically significant associations between postnatal MeHg exposure and any of the 17 neurodevelopmental outcomes after adjusting for prenatal MeHg exposure and other covariates. CONCLUSIONS: These findings are consistent with previous cross-sectional analyses of the SCDS Main Cohort. Continued follow-up of the entire NC2 cohort at later ages with repeated exposure measures is needed to further confirm these findings.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Efectos Tardíos de la Exposición Prenatal / Compuestos de Metilmercurio Límite: Animals / Female / Humans / Pregnancy País/Región como asunto: Africa Idioma: En Revista: Neurotoxicology Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Efectos Tardíos de la Exposición Prenatal / Compuestos de Metilmercurio Límite: Animals / Female / Humans / Pregnancy País/Región como asunto: Africa Idioma: En Revista: Neurotoxicology Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos