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The potential mechanism of the progression from latent to active tuberculosis based on the intestinal microbiota alterations.
Luo, Dan; Shi, Chong-Yu; Wei, Nian-Sa; Yang, Bo-Yi; Qin, Kai; Liu, Gang; Dong, Bai-Qing; Qin, Yi-Xiang; Qin, Xiao-Ling; Chen, Shi-Yi; Guo, Xiao-Jing; Gan, Li; Xu, Ruo-Lan; Li, Hai; Li, Jing.
Afiliación
  • Luo D; Department of Biostatistics, School of Public Health and Management, Guangxi University of Chinese Medicine, Nanning, China; Guangxi Key Laboratory of Translational Medicine for Treating High-Incidence Infectious Diseases with Integrative Medicine, Nanning, China.
  • Shi CY; The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
  • Wei NS; The Second Affiliated Hospital of Guangxi Medical University, Nanning, China.
  • Yang BY; The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
  • Qin K; The Second Affiliated Hospital of Guangxi Medical University, Nanning, China.
  • Liu G; Department of Biostatistics, School of Public Health and Management, Guangxi University of Chinese Medicine, Nanning, China.
  • Dong BQ; Department of Biostatistics, School of Public Health and Management, Guangxi University of Chinese Medicine, Nanning, China.
  • Qin YX; Department of Biostatistics, School of Public Health and Management, Guangxi University of Chinese Medicine, Nanning, China.
  • Qin XL; Department of Biostatistics, School of Public Health and Management, Guangxi University of Chinese Medicine, Nanning, China.
  • Chen SY; Department of Biostatistics, School of Public Health and Management, Guangxi University of Chinese Medicine, Nanning, China.
  • Guo XJ; Department of Biostatistics, School of Public Health and Management, Guangxi University of Chinese Medicine, Nanning, China.
  • Gan L; Department of Biostatistics, School of Public Health and Management, Guangxi University of Chinese Medicine, Nanning, China.
  • Xu RL; Department of Biostatistics, School of Public Health and Management, Guangxi University of Chinese Medicine, Nanning, China.
  • Li H; Department of Biostatistics, School of Public Health and Management, Guangxi University of Chinese Medicine, Nanning, China. Electronic address: lihai6609@foxmail.com.
  • Li J; Department of Physiology, School of Basic Medical Sciences, Guangxi Medical University, Nanning, China. Electronic address: lijing@gxmu.edu.cn.
Tuberculosis (Edinb) ; 143: 102413, 2023 12.
Article en En | MEDLINE | ID: mdl-37832478
INTRODUCTION: Tuberculosis (TB) poses a serious challenge to global health systems. The altered intestinal microbiota is associated with the pathogenesis of TB, but the exact links remain unclear. METHODS: 16 S rDNA sequencing was performed to comprehensively detect the changes in the intestinal microbiota of feces from active TB (ATB), latent TB infection (LTBI) and healthy controls (HC). RESULTS: The rarefaction curves demonstrated the sequencing results' validity. The alpha diversity was lowest in ATB, while highest in HC. Boxplot of beta diversity showed significant differences in every two groups. LDA Effect Size (LEfSe) Analysis revealed differences in probiotic bacteria like Romboutsia, Bifidobacterium and Lactobacillus in LTBI, and pro-inflammatory bacteria like R. gnavus, Streptococcus and Erysipelatoclostridium in ATB, corresponding to the cluster analysis. PICRUST2 analysis revealed the pentose phosphate pathway was active in ATB and LTBI (more active in ATB). The differences between the groups are statistically significant at the P<0.05 level. CONCLUSION: Our study indicated that from LTBI to ATB, some intestinal microbiota inhibit the synthesis of interferon (INF)-γ and interleukin (IL)-17, promoting the survival and spread of Mycobacterium tuberculosis (M. tb). In addition, the metabolites secreted by intestinal microbiota and dysbiosis in intestine also have an effect on the development of LTBI to ATB.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tuberculosis / Tuberculosis Latente / Microbioma Gastrointestinal / Mycobacterium tuberculosis Límite: Humans Idioma: En Revista: Tuberculosis (Edinb) Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tuberculosis / Tuberculosis Latente / Microbioma Gastrointestinal / Mycobacterium tuberculosis Límite: Humans Idioma: En Revista: Tuberculosis (Edinb) Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido