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Prognostic Impact of Early Administration of ß-Blockers in Critically Ill Patients with Acute Myocardial Infarction.
Zhang, Chong; Wang, Fei; Hao, Cuijun; Liang, Weiru; Hou, Tianhua; Xin, Jiayan; Su, Bin; Ning, Meng; Liu, Yingwu.
Afiliación
  • Zhang C; The Third Central Clinical College of Tianjin Medical University, Tianjin, China.
  • Wang F; Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, The Third Central Hospital of Tianjin, Tianjin, China.
  • Hao C; Artificial Cell Engineering Technology Research Center, The Third Central Hospital of Tianjin, Tianjin, China.
  • Liang W; Tianjin Institute of Hepatobiliary Disease, The Third Central Hospital of Tianjin, Tianjin, China.
  • Hou T; Department of Heart Center, The Third Central Hospital of Tianjin, Tianjin, China.
  • Xin J; The Third Central Clinical College of Tianjin Medical University, Tianjin, China.
  • Su B; Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, The Third Central Hospital of Tianjin, Tianjin, China.
  • Ning M; Artificial Cell Engineering Technology Research Center, The Third Central Hospital of Tianjin, Tianjin, China.
  • Liu Y; Tianjin Institute of Hepatobiliary Disease, The Third Central Hospital of Tianjin, Tianjin, China.
J Clin Pharmacol ; 64(4): 410-417, 2024 Apr.
Article en En | MEDLINE | ID: mdl-37830391
In critically ill patients with acute myocardial infarction (AMI), the relationship between the early administration of ß-blockers and the risks of in-hospital and long-term mortality remains controversial. Furthermore, there are conflicting evidences for the efficacy of the early administration of intravenous followed by oral ß-blockers in AMI. We conducted a retrospective analysis of critically ill patients with AMI who received the early administration of ß-blockers within 24 hours of admission. The data were extracted from the Medical Information Mart for Intensive Care IV database. We enrolled 2467 critically ill patients with AMI in the study, with 1355 patients who received the early administration of ß-blockers and 1112 patients who were non-users. Kaplan-Meier survival analysis and Cox proportional hazards models showed that the early administration of ß-blockers was associated with a lower risk of in-hospital mortality (adjusted hazard ratio [aHR] 0.52; 95% confidence interval [95%CI] 0.42-0.64), 1-year mortality (aHR 0.54, 95%CI 0.47-0.63), and 5-year mortality (aHR 0.60, 95%CI 0.52-0.69). Furthermore, the early administration of both oral ß-blockers and intravenous ß-blockers followed by oral ß-blockers may reduce the mortality risk, compared with non-users. The risks of in-hospital and long-term mortality were significantly decreased in patients who underwent revascularization with the early administration of ß-blockers. We found that the early administration of ß-blockers could lower the risks of in-hospital and long-term mortality. Furthermore, the early administration of both oral ß-blockers and intravenous ß-blockers followed by oral ß-blockers may reduce the mortality risk, compared with non-users. Notably, patients who underwent revascularization with the early administration of ß-blockers showed the lowest risks of in-hospital and long-term mortality.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad Crítica / Infarto del Miocardio Límite: Humans Idioma: En Revista: J Clin Pharmacol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad Crítica / Infarto del Miocardio Límite: Humans Idioma: En Revista: J Clin Pharmacol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido