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Single cell transcriptomics reveals recent CD8T cell receptor signaling in patients with coronary artery disease.
Iqneibi, Shahad; Saigusa, Ryosuke; Khan, Amir; Oliaeimotlagh, Mohammad; Armstrong Suthahar, Sujit Silas; Kumar, Sunil; Alimadadi, Ahmad; Durant, Christopher P; Ghosheh, Yanal; McNamara, Coleen A; Hedrick, Catherine C; Ley, Klaus.
Afiliación
  • Iqneibi S; Immunology Center of Georgia, Augusta University, Augusta, GA, United States.
  • Saigusa R; La Jolla Institute for Immunology, La Jolla, CA, United States.
  • Khan A; Immunology Center of Georgia, Augusta University, Augusta, GA, United States.
  • Oliaeimotlagh M; Immunology Center of Georgia, Augusta University, Augusta, GA, United States.
  • Armstrong Suthahar SS; La Jolla Institute for Immunology, La Jolla, CA, United States.
  • Kumar S; Immunology Center of Georgia, Augusta University, Augusta, GA, United States.
  • Alimadadi A; La Jolla Institute for Immunology, La Jolla, CA, United States.
  • Durant CP; La Jolla Institute for Immunology, La Jolla, CA, United States.
  • Ghosheh Y; La Jolla Institute for Immunology, La Jolla, CA, United States.
  • McNamara CA; Cardiovascular Research Center, Cardiovascular Division, Department of Medicine, University of Virginia, Charlottesville, VA, United States.
  • Hedrick CC; Immunology Center of Georgia, Augusta University, Augusta, GA, United States.
  • Ley K; La Jolla Institute for Immunology, La Jolla, CA, United States.
Front Immunol ; 14: 1239148, 2023.
Article en En | MEDLINE | ID: mdl-37828989
Coronary artery disease (CAD) is a major cause of death worldwide. The role of CD8+ T cells in CAD is unknown. Recent studies suggest a breakdown of tolerance in atherosclerosis, resulting in active T cell receptor (TCR) engagement with self-antigens. We hypothesized that TCR engagement would leave characteristic gene expression signatures. In a single cell RNA-sequencing analysis of CD8+ T cells from 30 patients with CAD and 30 controls we found significant enrichment of TCR signaling pathways in CAD+ subjects, suggesting recent TCR engagement. We also found significant enrichment of cytotoxic and exhaustion pathways in CAD cases compared to controls. Highly significant upregulation of TCR signaling in CAD indicates that CD8 T cells reactive to atherosclerosis antigens are prominent in the blood of CAD cases compared to controls.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Aterosclerosis Límite: Humans Idioma: En Revista: Front Immunol Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Aterosclerosis Límite: Humans Idioma: En Revista: Front Immunol Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza