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Observational cohort study protocol: neutrophil function and energetics in adults with pneumonia and sepsis - Pneumonia Metabolism in Ageing (PUMA).
Grudzinska, Frances S; Faniyi, Aduragbemi A; Scott, Aaron; Sapey, Elizabeth; Thickett, David R.
Afiliación
  • Grudzinska FS; Birmingham Acute Care Research, University of Birmingham College of Medical and Dental Sciences, Birmingham, UK F.Grudzinska@bham.ac.uk.
  • Faniyi AA; Birmingham Acute Care Research, University of Birmingham College of Medical and Dental Sciences, Birmingham, UK.
  • Scott A; Birmingham Acute Care Research, University of Birmingham College of Medical and Dental Sciences, Birmingham, UK.
  • Sapey E; Birmingham Acute Care Research, University of Birmingham College of Medical and Dental Sciences, Birmingham, UK.
  • Thickett DR; PIONEER Data Hub, University of Birmingham College of Medical and Dental Sciences, Birmingham, UK.
BMJ Open Respir Res ; 10(1)2023 10.
Article en En | MEDLINE | ID: mdl-37827807
INTRODUCTION: Community-acquired pneumonia has high mortality and is associated with significant healthcare costs. In older adults with community-acquired pneumonia neutrophil dysfunction has been identified and is associated with poor outcomes for patients. Immunometabolism is a rapidly developing field which links immune cell function to metabolism. This study aims to explore neutrophil metabolism in community-acquired pneumonia. METHODS AND ANALYSIS: Pneumonia Metabolism in Ageing study is a prospective observational study recruiting older adults hospitalised with community-acquired pneumonia to examine neutrophil function and metabolic status. Controls will be older adults with no acute illness. The primary endpoint is neutrophil chemotaxis. ETHICS AND DISSEMINATION: The study has ethical approval from the Research Ethics Committee Wales, reference 19/WA/0299. This study involves participants who may lack the capacity to consent to research involvement, in this situation, personal or professional assent will be sought. The results from this study will be submitted for publication in peer-reviewed journals and disseminated at local and international conferences.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonía / Infecciones Comunitarias Adquiridas / Sepsis Límite: Aged / Humans Idioma: En Revista: BMJ Open Respir Res Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonía / Infecciones Comunitarias Adquiridas / Sepsis Límite: Aged / Humans Idioma: En Revista: BMJ Open Respir Res Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido