Your browser doesn't support javascript.
loading
Molecular epidemiology and recombination of enterovirus D68 in China.
Shi, Yingying; Liu, Yongjuan; Wu, Yanli; Hu, Song; Sun, Binlian.
Afiliación
  • Shi Y; Department of Immunology, School of Medicine, Jianghan University, Wuhan, Hubei 430056, China.
  • Liu Y; Department of Central Laboratory, the Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, Jiangsu 222002, China.
  • Wu Y; Department of Immunology, School of Medicine, Jianghan University, Wuhan, Hubei 430056, China.
  • Hu S; Wuhan Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, China.
  • Sun B; Wuhan Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, China. Electronic address: binlian17@jhun.edu.cn.
Infect Genet Evol ; 115: 105512, 2023 11.
Article en En | MEDLINE | ID: mdl-37827347
Enterovirus D68 (EV-D68), a member of Enterovirus genus of the Picornaviridae family, mainly causes respiratory system-related diseases as well as neurological complications in some patients. At present, there is no effective vaccine or treatment for the virus. The aim of this research was to systematically analyse the molecular epidemiology, recombination and changes in the epitope of EV-D68 in China from 2008 to 2022. Through phylogenetic analysis based on VP1 sequences, it was found that there was limited information about EV-D68 infection before 2011 and that EV-D68 infection was dominated by the A2 gene subtype from 2011 to 2013 and the B3 genotype from 2014 to 2018, during which A2 and B3 were coprevalent and alternately prevalent. We also constructed a phylogenetic tree using the EV-D68 full-length genome sequences, and the genotype of each sequence was consistent with that of the VP1 sequence evolutionary tree. Recombination analysis showed that MH341715 underwent intertypic recombination with the A2 genotype MH341729 at the 5' untranslated region (5'UTR) and that P1-P3 underwent recombination with the B3 genotype MH341712. The capsid protein VP1 is one of the most important structural proteins. In VP1, the BC-loop (89-105 amino acids) and DE-loop (140-152 amino acids) are the most variable domains on the surface of the virus and are associated with epitopes. In this study, it was found that the dominant amino acid composition of the BC-loop and DE-loop continued to change with the epidemic of the virus; the amino acid composition also differed in different regions of the same genotypes. The ongoing genomic and molecular epidemiology of EV-D68 remains important for predicting emergence of new viruses and preventing major outbreaks of respiratory diseases.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones del Sistema Respiratorio / Enterovirus / Enterovirus Humano D / Infecciones por Enterovirus Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Infect Genet Evol Asunto de la revista: BIOLOGIA / DOENCAS TRANSMISSIVEIS / GENETICA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones del Sistema Respiratorio / Enterovirus / Enterovirus Humano D / Infecciones por Enterovirus Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Infect Genet Evol Asunto de la revista: BIOLOGIA / DOENCAS TRANSMISSIVEIS / GENETICA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos