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Temporal disparity of action potentials triggered in axon initial segments and distal axons in the neocortex.
Rózsa, Márton; Tóth, Martin; Oláh, Gáspár; Baka, Judith; Lákovics, Rajmund; Barzó, Pál; Tamás, Gábor.
Afiliación
  • Rózsa M; ELKH-SZTE Research Group for Cortical Microcircuits, University of Szeged, Szeged, Hungary.
  • Tóth M; ELKH-SZTE Research Group for Cortical Microcircuits, University of Szeged, Szeged, Hungary.
  • Oláh G; ELKH-SZTE Research Group for Cortical Microcircuits, University of Szeged, Szeged, Hungary.
  • Baka J; ELKH-SZTE Research Group for Cortical Microcircuits, University of Szeged, Szeged, Hungary.
  • Lákovics R; ELKH-SZTE Research Group for Cortical Microcircuits, University of Szeged, Szeged, Hungary.
  • Barzó P; Department of Neurosurgery, University of Szeged, Szeged, Hungary.
  • Tamás G; ELKH-SZTE Research Group for Cortical Microcircuits, University of Szeged, Szeged, Hungary.
Sci Adv ; 9(41): eade4511, 2023 10 13.
Article en En | MEDLINE | ID: mdl-37824608
Neural population activity determines the timing of synaptic inputs, which arrive to dendrites, cell bodies, and axon initial segments (AISs) of cortical neurons. Action potential initiation in the AIS (AIS-APs) is driven by input integration, and the phase preference of AIS-APs during network oscillations is characteristic to cell classes. Distal regions of cortical axons do not receive synaptic inputs, yet experimental induction protocols can trigger retroaxonal action potentials (RA-APs) in axons distal from the soma. We report spontaneously occurring RA-APs in human and rodent cortical interneurons that appear uncorrelated to inputs and population activity. Network-linked triggering of AIS-APs versus input-independent timing of RA-APs of the same interneurons results in disparate temporal contribution of a single cell to in vivo network operation through perisomatic and distal axonal firing.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neocórtex / Segmento Inicial del Axón Límite: Humans Idioma: En Revista: Sci Adv Año: 2023 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neocórtex / Segmento Inicial del Axón Límite: Humans Idioma: En Revista: Sci Adv Año: 2023 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Estados Unidos