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Association of AST/ALT (De Ritis) ratio with sarcopenia in a Chinese population of community-dwelling elderly.
Wu, Cheng; Wang, Quan; Zhou, Chun-Ya; Sun, Hui-Xian; Lin, Yu-Shuang; Jiao, Xin-Feng; Lu, Xiang; Xu, Jin-Shui; Shen, Zheng-Kai; Guo, Yan; Gao, Wei.
Afiliación
  • Wu C; Department of Geriatrics, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China.
  • Wang Q; Department of Geriatrics, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China.
  • Zhou CY; Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
  • Sun HX; Department of Rheumatology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China.
  • Lin YS; Department of Geriatrics, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China.
  • Jiao XF; Department of Geriatrics, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China.
  • Lu X; Department of Geriatrics, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China.
  • Xu JS; Department of Geriatrics, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China.
  • Shen ZK; Jiangsu Province Center for Disease Control and Prevention, Nanjing, China.
  • Guo Y; Jiangsu Province Center for Disease Control and Prevention, Nanjing, China.
  • Gao W; Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Heliyon ; 9(10): e20427, 2023 Oct.
Article en En | MEDLINE | ID: mdl-37822616
Background: The aspartate aminotransferase/alanine aminotransferase (AST/ALT) ratio, also known as De Ritis ratio, has been reportedly associated with malnutrition which plays a crucial role in sarcopenia. The aim of this study was to examine the relationship between AST/ALT ratio and sarcopenia in the Chinese community-dwelling elderly. Methods: A cross-sectional study with 2751 participants (1343 men and 1408 women) aged ≥60 years was performed. Appendicular skeletal muscle mass index (ASMI), grip strength, and gait speed were measured to diagnose sarcopenia according to the latest Asian Working Group for Sarcopenia (AWGS) consensus. The association of AST/ALT ratio with sarcopenia was examined using logistic regression analysis. Results: The prevalence of sarcopenia in the present study was 4.4%. AST/ALT ratio was higher in the sarcopenia group than in the non-sarcopenia group (1.30 ± 0.33 vs. 1.16 ± 0.62, P = 0.010). AST/ALT ratio was negatively correlated with the components of sarcopenia, including ASMI, grip strength, and gait speed. Logistic regression analysis indicated that high AST/ALT ratio (>1.20) was associated with increased risk of sarcopenia even after adjustment for potential confounders (adjusted OR = 2.33, 95%CI = 1.48-3.68, P < 0.001). Stratification analyses indicated that the association of high AST/ALT ratio with high risk of sarcopenia was more significant in males and the elderly with ≥70 years. Conclusions: Our findings demonstrate that high AST/ALT ratio is associated with increased risk of sarcopenia in a Chinese population of community-dwelling elderly.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Risk_factors_studies Idioma: En Revista: Heliyon Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Risk_factors_studies Idioma: En Revista: Heliyon Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido