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Association between fractional exhaled nitric oxide and therapeutic adherence to controller management in pediatric asthma patients.
Cleves, Daniela; Vargas, Pedro; Acuña-Cordero, Ranniery; Aguilera-Otalvaro, Paula; Camargo, Bethy; Aristizábal-Duque, Ricardo; Rodríguez-Martínez, Carlos E.
Afiliación
  • Cleves D; Department of Pediatric Pulmonology, School of Medicine, Universidad El Bosque, Bogota, Colombia.
  • Vargas P; Department of Pediatric Pulmonology, School of Medicine, Universidad El Bosque, Bogota, Colombia.
  • Acuña-Cordero R; Department of Pediatric Pulmonology, Hospital Militar Central, Bogotá, Colombia.
  • Aguilera-Otalvaro P; Department of Pediatrics, Hospital Militar Central, Bogotá, Colombia.
  • Camargo B; Department of Pediatrics, Hospital Militar Central, Bogotá, Colombia.
  • Aristizábal-Duque R; Department of Pediatric Pulmonology, School of Medicine, Universidad El Bosque, Bogota, Colombia.
  • Rodríguez-Martínez CE; Department of Pediatric Pulmonology, School of Medicine, Universidad El Bosque, Bogota, Colombia.
Pediatr Pulmonol ; 59(1): 121-128, 2024 Jan.
Article en En | MEDLINE | ID: mdl-37818776
ABSTRACT

OBJECTIVES:

Guidelines for asthma management recommend, before establishing additional therapeutic behaviors, to confirm correct use and adequate therapeutic adherence to treatment. Evidence exists on the use of fractional exhaled nitric oxide (FeNO) values for monitoring therapeutic adherence in adults. It is important to establish whether there is a correlation between FeNO and therapeutic adherence in children. This study aims to provide new knowledge about the relationship between FeNO and therapeutic adherence in asthmatic children. MATERIALS AND

METHODS:

Analytical cross-sectional study including asthma patients 5-18 years of age, attending follow-up at Hospital Militar Central (HMC) between May and November 2022 in Colombia. A sociodemographic survey was carried out, followed by the Pediatric Inhaler Adherence Questionnaire (PIAQ), and asthma control test (ACT) or childhood asthma control test (cACT). We defined adequate therapeutic adherence as not missing a single application of inhaled steroids in the last 15 days according to PIAQ. A poisson regression model was carried out including relevant predictors for therapeutic adherence such as FeNO values, age, tobacco exposure at home, atopy, and time since initiation of use of inhaled controller.

RESULTS:

Eighty-two children with a median age of 10 years (interquartile range 7-12 years) were included. Adequate therapeutic adherence was reported by 68.3%. After adjusting for age, sex, exposure to cigarette smoke, duration of controller therapy, and atopy, FeNO < 20 ppb was independently associated with adequate therapeutic adherence (RR = 1.5, p = .04, 95% confidence interval 1.03-2.19).

CONCLUSIONS:

FeNO values seem to be useful to identify pediatric patients with asthma who have adequate adherence to inhaled steroids in a MIC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Asma / Hipersensibilidad Inmediata Tipo de estudio: Guideline / Observational_studies / Prognostic_studies / Qualitative_research / Risk_factors_studies Límite: Adult / Child / Humans Idioma: En Revista: Pediatr Pulmonol Asunto de la revista: PEDIATRIA Año: 2024 Tipo del documento: Article País de afiliación: Colombia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Asma / Hipersensibilidad Inmediata Tipo de estudio: Guideline / Observational_studies / Prognostic_studies / Qualitative_research / Risk_factors_studies Límite: Adult / Child / Humans Idioma: En Revista: Pediatr Pulmonol Asunto de la revista: PEDIATRIA Año: 2024 Tipo del documento: Article País de afiliación: Colombia Pais de publicación: Estados Unidos