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Resting-state prefrontal EEG biomarker in correlation with postoperative delirium in elderly patients.
Kim, Jeongmin; Park, Sujung; Kim, Keung-Nyun; Ha, Yoon; Shin, Sang-Jun; Cha, Wonseok; Lee, Ki-Young; Choi, Jungmi; Koo, Bon-Nyeo.
Afiliación
  • Kim J; Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Park S; Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Kim KN; Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Ha Y; Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Shin SJ; Department of Neurosurgery, Spine and Spinal Cord Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Cha W; Department of Neurosurgery, Spine and Spinal Cord Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Lee KY; POSTECH Biotech Center, Pohang University of Science and Technology, Pohang, Republic of Korea.
  • Choi J; Department of Biomedical Systems Informatics, Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Koo BN; Human Anti-Aging Standards Research Institute, Gyeongsangnam-Do, Republic of Korea.
Front Aging Neurosci ; 15: 1224264, 2023.
Article en En | MEDLINE | ID: mdl-37818480
Postoperative delirium (POD) is associated with adverse outcomes in elderly patients after surgery. Electroencephalography (EEG) can be used to develop a potential biomarker for degenerative cerebral dysfunctions, including mild cognitive impairment and dementia. This study aimed to explore the relationship between preoperative EEG and POD. We included 257 patients aged >70 years who underwent spinal surgery. We measured the median dominant frequency (MDF), which is a resting-state EEG biomarker involving intrinsic alpha oscillations that reflect an idle cortical state, from the prefrontal regions. Additionally, the mini-mental state examination and Montreal cognitive assessment (MoCA) were performed before surgery as well as 5 days after surgery. For long-term cognitive function follow up, the telephone interview for cognitive status™ (TICS) was performed 1 month and 1 year after surgery. Fifty-two (20.2%) patients were diagnosed with POD. A multivariable logistic regression analysis that included age, MoCA score, Charlson comorbidity index score, Mini Nutritional Assessment, and the MDF as variables revealed that the MDF had a significant odds ratio of 0.48 (95% confidence interval 0.27-0.85). Among the patients with POD, the postoperative neurocognitive disorders could last up to 1 year. Low MDF on preoperative EEG was associated with POD in elderly patients undergoing surgery. EEG could be a novel potential tool for identifying patients at a high risk of POD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Front Aging Neurosci Año: 2023 Tipo del documento: Article Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Front Aging Neurosci Año: 2023 Tipo del documento: Article Pais de publicación: Suiza