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Matrix density regulates adipocyte phenotype.
Ky, Alexander; McCoy, Atticus J; Flesher, Carmen G; Friend, Nicole E; Li, Jie; Akinleye, Kore; Patsalis, Christopher; Lumeng, Carey N; Putnam, Andrew J; O'Rourke, Robert W.
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  • Ky A; Department of Surgery, University of Michigan, Ann Arbor, MI, USA.
  • McCoy AJ; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
  • Flesher CG; Department of Surgery, University of Michigan, Ann Arbor, MI, USA.
  • Friend NE; Graduate Program, University of Pennsylvania, Philadelphia, PA, USA.
  • Li J; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
  • Akinleye K; Department of Surgery, University of Michigan, Ann Arbor, MI, USA.
  • Patsalis C; Department of Surgery, University of Michigan, Ann Arbor, MI, USA.
  • Lumeng CN; Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
  • Putnam AJ; Department of Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
  • O'Rourke RW; Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI, USA.
Adipocyte ; 12(1): 2268261, 2023 12.
Article en En | MEDLINE | ID: mdl-37815174
Alterations of the extracellular matrix contribute to adipose tissue dysfunction in metabolic disease. We studied the role of matrix density in regulating human adipocyte phenotype in a tunable hydrogel culture system. Lipid accumulation was maximal in intermediate hydrogel density of 5 weight %, relative to 3% and 10%. Adipogenesis and lipid and oxidative metabolic gene pathways were enriched in adipocytes in 5% relative to 3% hydrogels, while fibrotic gene pathways were enriched in 3% hydrogels. These data demonstrate that the intermediate density matrix promotes a more adipogenic, less fibrotic adipocyte phenotype geared towards increased lipid and aerobic metabolism. These observations contribute to a growing literature describing the role of matrix density in regulating adipose tissue function.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tejido Adiposo / Adipocitos Límite: Humans Idioma: En Revista: Adipocyte Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tejido Adiposo / Adipocitos Límite: Humans Idioma: En Revista: Adipocyte Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos