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Prognostic factors for multisystem inflammatory syndrome in children: A systematic review and meta-analysis.
Rayner, Daniel G; Gou, David; Chen, Jason Z X; Zhu, Evelyn; Lin, Vallen W; Fu, Nicole.
Afiliación
  • Rayner DG; Department of Health Research Methods, Evidence, and Impact, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
  • Gou D; Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
  • Chen JZX; Michael G. DeGroote School of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
  • Zhu E; Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
  • Lin VW; Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
  • Fu N; Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Acta Paediatr ; 113(1): 39-47, 2024 01.
Article en En | MEDLINE | ID: mdl-37815153
ABSTRACT

AIM:

Multisystem inflammatory syndrome in children (MIS-C) is a novel condition that can occur post-SARS-CoV-2 infection in children and adolescents. There is a paucity of evidence on the prognostic factors associated with MIS-C. The aim of this systematic review and meta-analysis was to summarise the prognostic factors for MIS-C development.

METHODS:

Five databases were systematically searched from January 2020 to May 2023 for studies reporting on prognostic factors for MIS-C using multivariable regression models. Random-effects meta-analyses were conducted to pool odds ratios for each prognostic factor. Risk of bias was rated using QUIPS and the GRADE framework was used to assess the certainty of evidence for each unique factor.

RESULTS:

Twelve observational studies (N = 18 024) were included, and 13 unique prognostic factors were amenable to meta-analysis. With moderate certainty, age <12 years, male sex and Black race probably increase the risk of MIS-C. Malignancy and underlying respiratory disease probably decrease the risk of MIS-C. Low-certainty evidence suggests that Asian race may increase the risk of MIS-C, and comorbidity may decrease the risk of MIS-C.

CONCLUSION:

Current literature presents several prognostic factors related to MIS-C following SARS-CoV-2 infection. Further research is necessary to elucidate the pathophysiologic mechanisms related to MIS-C.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: COVID-19 Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Adolescent / Child / Humans / Male Idioma: En Revista: Acta Paediatr Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Noruega
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: COVID-19 Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Adolescent / Child / Humans / Male Idioma: En Revista: Acta Paediatr Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Noruega