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Bone disease imaging through the near-infrared-II window.
Mi, Chao; Zhang, Xun; Yang, Chengyu; Wu, Jianqun; Chen, Xinxin; Ma, Chenguang; Wu, Sitong; Yang, Zhichao; Qiao, Pengzhen; Liu, Yang; Wu, Weijie; Guo, Zhiyong; Liao, Jiayan; Zhou, Jiajia; Guan, Ming; Liang, Chao; Liu, Chao; Jin, Dayong.
Afiliación
  • Mi C; UTS-SUSTech Joint Research Centre for Biomedical Materials and Devices, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, China. mic@sustech.edu.cn.
  • Zhang X; Institute for Biomedical Materials and Devices (IBMD), Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia. mic@sustech.edu.cn.
  • Yang C; National Institute of Extremely-Weak Magnetic Field Infrastructure, Hangzhou, China. mic@sustech.edu.cn.
  • Wu J; Shenzhen Light Life Technology Co., Ltd., Shenzhen, China. mic@sustech.edu.cn.
  • Chen X; UTS-SUSTech Joint Research Centre for Biomedical Materials and Devices, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, China.
  • Ma C; Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, China.
  • Wu S; Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, China.
  • Yang Z; Department of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.
  • Qiao P; UTS-SUSTech Joint Research Centre for Biomedical Materials and Devices, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, China.
  • Liu Y; UTS-SUSTech Joint Research Centre for Biomedical Materials and Devices, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, China.
  • Wu W; Institute for Biomedical Materials and Devices (IBMD), Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia.
  • Guo Z; UTS-SUSTech Joint Research Centre for Biomedical Materials and Devices, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, China.
  • Liao J; Institute for Biomedical Materials and Devices (IBMD), Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia.
  • Zhou J; UTS-SUSTech Joint Research Centre for Biomedical Materials and Devices, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, China.
  • Guan M; Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, China.
  • Liang C; UTS-SUSTech Joint Research Centre for Biomedical Materials and Devices, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, China.
  • Liu C; UTS-SUSTech Joint Research Centre for Biomedical Materials and Devices, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, China.
  • Jin D; National Institute of Extremely-Weak Magnetic Field Infrastructure, Hangzhou, China.
Nat Commun ; 14(1): 6287, 2023 10 09.
Article en En | MEDLINE | ID: mdl-37813832
Skeletal disorders are commonly diagnosed by X-ray imaging, but the radiation limits its use. Optical imaging through the near-infrared-II window (NIR-II, 1000-1700 nm) can penetrate deep tissues without radiation risk, but the targeting of contrast agent is non-specific. Here, we report that lanthanide-doped nanocrystals can passively target the bone marrow, which can be effective for over two months. We therefore develop the high-resolution NIR-II imaging method for bone disease diagnosis, including the 3D bone imaging instrumentation to show the intravital bone morphology. We demonstrate the monitoring of 1 mm bone defects with spatial resolution comparable to the X-ray imaging result. Moreover, NIR-II imaging can reveal the early onset inflammation as the synovitis in the early stage of rheumatoid arthritis, comparable to micro computed tomography (µCT) in diagnosis of osteoarthritis, including the symptoms of osteophyte and hyperostosis in the knee joint.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteoartritis / Enfermedades Óseas / Elementos de la Serie de los Lantanoides Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteoartritis / Enfermedades Óseas / Elementos de la Serie de los Lantanoides Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido