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The antibacterial activity of a photoactivatable diarylacetylene against Gram-positive bacteria.
Waite, Ryan; Adams, Candace T; Chisholm, David R; Sims, C H Cole; Hughes, Joshua G; Dias, Eva; White, Emily A; Welsby, Kathryn; Botchway, Stanley W; Whiting, Andrew; Sharples, Gary J; Ambler, Carrie A.
Afiliación
  • Waite R; Department of Biosciences, Durham University, Science Site, Durham, United Kingdom.
  • Adams CT; LightOx Limited, Newcastle, United Kingdom.
  • Chisholm DR; LightOx Limited, Newcastle, United Kingdom.
  • Sims CHC; LightOx Limited, Newcastle, United Kingdom.
  • Hughes JG; Department of Biosciences, Durham University, Science Site, Durham, United Kingdom.
  • Dias E; LightOx Limited, Newcastle, United Kingdom.
  • White EA; Department of Physics, Durham University, Science Site, Durham, United Kingdom.
  • Welsby K; LightOx Limited, Newcastle, United Kingdom.
  • Botchway SW; Department of Biosciences, Durham University, Science Site, Durham, United Kingdom.
  • Whiting A; Central Laser Facility, Research Complex at Harwell, Science and Technology Facilities Council, Rutherford Appleton Laboratory, Harwell, United Kingdom.
  • Sharples GJ; Central Laser Facility, Research Complex at Harwell, Science and Technology Facilities Council, Rutherford Appleton Laboratory, Harwell, United Kingdom.
  • Ambler CA; LightOx Limited, Newcastle, United Kingdom.
Front Microbiol ; 14: 1243818, 2023.
Article en En | MEDLINE | ID: mdl-37808276
The emergence of antibiotic resistance is a growing threat to human health, and therefore, alternatives to existing compounds are urgently needed. In this context, a novel fluorescent photoactivatable diarylacetylene has been identified and characterised for its antibacterial activity, which preferentially eliminates Gram-positive over Gram-negative bacteria. Experiments confirmed that the Gram-negative lipopolysaccharide-rich outer surface is responsible for tolerance, as strains with reduced outer membrane integrity showed increased susceptibility. Additionally, bacteria deficient in oxidative damage repair pathways also displayed enhanced sensitivity, confirming that reactive oxygen species production is the mechanism of antibacterial activity. This new diarylacetylene shows promise as an antibacterial agent against Gram-positive bacteria that can be activated in situ, potentially for the treatment of skin infections.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Microbiol Año: 2023 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Microbiol Año: 2023 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Suiza