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Cerebral Spinal Fluid Parameters Following CD19-Targeted Therapies in Children and Young Adults.
Leib, Shiran; Bielorai, Bella; Vernitsky, Helly; Aharony-Tevet, Yarden; Toren, Amos; Jacoby, Elad.
Afiliación
  • Leib S; Division of Pediatric Hematology and Oncology, The Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer.
  • Bielorai B; Division of Pediatric Hematology and Oncology, The Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer.
  • Vernitsky H; Faculty of Medicine, Tel Aviv University, Tel Aviv.
  • Aharony-Tevet Y; Hematology Lab, Sheba Medical Center, Tel Hashomer.
  • Toren A; Faculty of Medicine, Tel Aviv University, Tel Aviv.
  • Jacoby E; Immunotherapy Lab, Sheba Medical Center, Tel Hashomer, Israel.
J Pediatr Hematol Oncol ; 46(1): 29-32, 2024 01 01.
Article en En | MEDLINE | ID: mdl-37807185
The presence of leukocytes in the cerebral spinal fluid (CSF) of patients with acute lymphoblastic leukemia may indicate a relapse in the central nervous system. CD19-directed immunotherapy may increase the blood-brain barrier permeability, leading to neurologic toxicity and infiltrate the CNS. We studied the CSF cell and protein content in 71 consecutive patients who received either CD19 chimeric antigen receptor T cells or blinatumomab. Responding patients had an incidence of 66% and 61% of pleocytosis following blinatumomab or chimeric antigen receptor T cells, respectively. CSF parameters did not correlate with toxicity or prior CNS disease. Routine CSF flow cytometry following immunotherapy to distinguish T-cell infiltration from CNS relapse should be considered.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia-Linfoma Linfoblástico de Células Precursoras / Receptores Quiméricos de Antígenos Límite: Adult / Child / Humans Idioma: En Revista: J Pediatr Hematol Oncol Asunto de la revista: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia-Linfoma Linfoblástico de Células Precursoras / Receptores Quiméricos de Antígenos Límite: Adult / Child / Humans Idioma: En Revista: J Pediatr Hematol Oncol Asunto de la revista: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos