Your browser doesn't support javascript.
loading
Identification of novel inhibitors from Urtica spp against TNBC targeting JAK2 receptor for breast cancer therapy.
Upreti, Shobha; Muduli, Kartik; Pradhan, Jagannath; Elangovan, Selvakumar; Samant, Mukesh.
Afiliación
  • Upreti S; Cell and Molecular Biology Laboratory, Department of Zoology, Soban Singh Jeena University Campus, Almora, Uttarakhand, India.
  • Muduli K; Department of Zoology, Kumaun University, Nainital, Uttarakhand, India.
  • Pradhan J; School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT) Deemed to be University, Patia, Bhubaneswar, 751024, Odisha, India.
  • Elangovan S; School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT) Deemed to be University, Patia, Bhubaneswar, 751024, Odisha, India.
  • Samant M; School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT) Deemed to be University, Patia, Bhubaneswar, 751024, Odisha, India.
Med Oncol ; 40(11): 326, 2023 Oct 08.
Article en En | MEDLINE | ID: mdl-37806999
Breast cancer is the most prevalent form of cancer in women globally, and TNBC (triple-negative breast cancer) is its aggressive type since it lacks the usual targets. JAK2/STAT3 pathway can be an important lead in anticancer drug discovery, as restraining the downstream signalling of this pathway results in the induction of cell apoptosis. Moreover, various limitations associated with chemotherapy are the reason to find an alternative herbal-based therapy. For this study, we collected Urtica dioica and U. parviflora from different regions of Uttarakhand, followed by preparation of their leaf and stem extracts in different solvents. The GC-MS analysis of these extracts revealed a total of 175 compounds to be present in them. Further, by molecular docking approach, we studied the interaction between these compounds and JAK2, and 12 major compounds with better binding energy than the control Paclitaxel were identified. In addition, the selected hits were also reported to display better pharmacokinetic properties. Moreover, extracts from both the Urtica spp. displayed significant anticancer activity against MDA-MB-231(TNBC cell line) and exhibited lower cytotoxicity in healthy cell lines, i.e. HEK293T, indicating that these extracts were safer to use. Hence, the findings in our study can be crucial in the area of herbal-based target-specific drug development against breast cancer.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama Triple Negativas Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Female / Humans Idioma: En Revista: Med Oncol Asunto de la revista: NEOPLASIAS Año: 2023 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama Triple Negativas Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Female / Humans Idioma: En Revista: Med Oncol Asunto de la revista: NEOPLASIAS Año: 2023 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos