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Potential anti-amoebic activity of sulfonate- and sulfamate-containing carboxamide derivatives against pathogenic Acanthamoeba castellanii belonging to the genotype T4.
Akbar, Noor; Siddiqui, Ruqaiyyah; El-Gamal, Mohammed I; Zaraei, Seyed-Omar; Saeed, Balsam Qubais; Alawfi, Bader Saleem; Khan, Naveed Ahmed.
Afiliación
  • Akbar N; Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah 27272, United Arab Emirates; Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates.
  • Siddiqui R; Microbiota Research Center, Istinye University, Istanbul 34010, Turkey; College of Arts and Sciences, American University of Sharjah, Sharjah 26666, United Arab Emirates.
  • El-Gamal MI; Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah 27272, United Arab Emirates; Department of Medicinal Chemistry, College of Pharmacy, University of Sharjah, Sharjah 27272, United Arab Emirates; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura Universi
  • Zaraei SO; Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah 27272, United Arab Emirates.
  • Saeed BQ; Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah 27272, United Arab Emirates; Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates.
  • Alawfi BS; Department of Medical Laboratories Technology, College of Applied Medical Sciences, Taibah University, Madinah 42353, Saudi Arabia.
  • Khan NA; Microbiota Research Center, Istinye University, Istanbul 34010, Turkey; Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates. Electronic address: naveed5438@gmail.com.
Parasitol Int ; 98: 102814, 2024 Feb.
Article en En | MEDLINE | ID: mdl-37806551
ABSTRACT
Acanthamoeba are ubiquitously distributed in the environment and can cause infection of the central nervous system as well a sight-threatening eye infection. Herein, the potential anti-amoebic activity of a series of sulfonate/sulfamate derivatives against pathogenic A. castellanii was evaluated. These compounds were tested using several assays namely amoebicidal, adhesion, excystation, cytotoxic, and cytopathogenicity. Amoebicidal assays revealed that the selected compounds reduced amoebae viability significantly (P < 0.05), and exhibited IC50 values at two-digit micromolar concentrations. Sulfamate derivatives 1j & 1k inhibited 50% of amoebae at 30.65 µM and 27.21 µM, respectively. The tested compounds blocked amoebae binding to host cells as well as inhibited amoebae excystation. Notably, the selected derivatives exhibited minimal human cell cytotoxicity but reduced parasite-mediated host cell damage. Overall, our study showed that sulfamate derivatives 1j & 1k have anti-amoebic potential and offer a promising avenue in the development of potential anti-amoebic drug candidates.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Acanthamoeba castellanii / Amebicidas Límite: Humans Idioma: En Revista: Parasitol Int Asunto de la revista: PARASITOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Emiratos Árabes Unidos Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Acanthamoeba castellanii / Amebicidas Límite: Humans Idioma: En Revista: Parasitol Int Asunto de la revista: PARASITOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Emiratos Árabes Unidos Pais de publicación: Países Bajos