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Functional Crosstalk between Discrete Indole Terpenoid Gene Clusters in Tolypocladium album.
Hibbard, Taylor R; McLellan, Rose M; Stevenson, Luke J; Richardson, Alistair T; Nicholson, Matthew J; Parker, Emily J.
Afiliación
  • Hibbard TR; Ferrier Research Institute, Victoria University of Wellington, Wellington 6012, New Zealand.
  • McLellan RM; Maurice Wilkins Centre for Molecular Biodiscovery, Victoria University of Wellington, Wellington 6012, New Zealand.
  • Stevenson LJ; Ferrier Research Institute, Victoria University of Wellington, Wellington 6012, New Zealand.
  • Richardson AT; Maurice Wilkins Centre for Molecular Biodiscovery, Victoria University of Wellington, Wellington 6012, New Zealand.
  • Nicholson MJ; Ferrier Research Institute, Victoria University of Wellington, Wellington 6012, New Zealand.
  • Parker EJ; Maurice Wilkins Centre for Molecular Biodiscovery, Victoria University of Wellington, Wellington 6012, New Zealand.
Org Lett ; 25(41): 7470-7475, 2023 10 20.
Article en En | MEDLINE | ID: mdl-37797949
Indole terpenoids make up a large group of secondary metabolites that display an enticing array of bioactivities. While indole diterpene (IDT) and rarely indole sesquiterpene (IST) pathways have been found individually in filamentous fungi, here we show that both cluster types are encoded within the genome of Tolypocladium album. Through heterologous reconstruction, we demonstrate the SES cluster encodes for IST biosynthesis and can tailor IDT substrates produced by the TER cluster.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diterpenos / Hypocreales Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Nueva Zelanda Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diterpenos / Hypocreales Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Nueva Zelanda Pais de publicación: Estados Unidos