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Benign recurrent lymphocytic meningitis (Mollaret's meningitis) in Denmark: a nationwide cohort study.
Petersen, Pelle Trier; Bodilsen, Jacob; Jepsen, Micha Phill Grønholm; Hansen, Birgitte Rønde; Storgaard, Merete; Larsen, Lykke; Helweg-Larsen, Jannik; Wiese, Lothar; Lüttichau, Hans Rudolf; Andersen, Christian Østergaard; Mogensen, Trine Hyrup; Nielsen, Henrik; Brandt, Christian Thomas.
Afiliación
  • Petersen PT; Department of Pulmonary and Infectious Diseases, Nordsjaellands Hospital, Hillerød, Denmark.
  • Bodilsen J; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Jepsen MPG; Department of Infectious Diseases, Aalborg University Hospital, Aalborg, Denmark.
  • Hansen BR; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
  • Storgaard M; Department of Pulmonary and Infectious Diseases, Nordsjaellands Hospital, Hillerød, Denmark.
  • Larsen L; Department of Infectious Diseases, Hvidovre Hospital, Hvidovre, Denmark.
  • Helweg-Larsen J; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.
  • Wiese L; Department of Infectious Diseases, Odense University Hospital, Odense, Denmark.
  • Lüttichau HR; Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark.
  • Andersen CØ; Department of Medicine, Zealand University Hospital, Roskilde, Denmark.
  • Mogensen TH; Department of Infectious Diseases, Herlev Hospital, Herlev, Denmark.
  • Nielsen H; Department of Clinical Microbiology, Hvidovre Hospital, Hvidovre, Denmark.
  • Brandt CT; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.
Eur J Neurol ; 31(1): e16081, 2024 01.
Article en En | MEDLINE | ID: mdl-37797296
ABSTRACT
BACKGROUND AND

PURPOSE:

Data on clinical features and outcomes of benign recurrent lymphocytic meningitis (BRLM) are limited.

METHODS:

This was a nationwide population-based cohort study of all adults hospitalized for BRLM associated with herpes simplex virus type 2 (HSV-2) at the departments of infectious diseases in Denmark from 2015 to 2020. Patients with single-episode HSV-2 meningitis were included for comparison.

RESULTS:

Forty-seven patients with BRLM (mean annual incidence 1.2/1,000,000 adults) and 118 with single-episode HSV-2 meningitis were included. The progression risk from HSV-2 meningitis to BRLM was 22% (95% confidence interval [CI] 15%-30%). The proportion of patients with the triad of headache, neck stiffness and photophobia/hyperacusis was similar between BRLM and single-episode HSV-2 meningitis (16/43 [37%] vs. 46/103 [45%]; p = 0.41), whilst the median cerebrospinal fluid leukocyte count was lower in BRLM (221 cells vs. 398 cells; p = 0.02). Unfavourable functional outcomes (Glasgow Outcome Scale score of 1-4) were less frequent in BRLM at all post-discharge follow-up visits. During the study period, 10 (21%) patients with BRLM were hospitalized for an additional recurrence (annual rate 6%, 95% CI 3%-12%). The hazard ratio for an additional recurrence was 3.93 (95% CI 1.02-15.3) for patients with three or more previous episodes of meningitis.

CONCLUSIONS:

Clinical features of BRLM were similar to those of single-episode HSV-2 meningitis, whilst post-discharge outcomes were more favourable. Patients with three or more previous episodes of meningitis had higher risk of an additional recurrence.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Meningitis Aséptica / Meningitis Viral Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adult / Humans País/Región como asunto: Europa Idioma: En Revista: Eur J Neurol Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Meningitis Aséptica / Meningitis Viral Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adult / Humans País/Región como asunto: Europa Idioma: En Revista: Eur J Neurol Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Reino Unido