Your browser doesn't support javascript.
loading
Different benefits of adaptive radiotherapy for different histologies of NSCLC.
Tvilum, Marie; Lutz, Christina Maria; Knap, Marianne Marquard; Hoffmann, Lone; Khalil, Azza Ahmed; Holt, Marianne Ingerslev; Kandi, Maria; Schmidt, Hjørdis Hjalting; Appelt, Ane L; Alber, Markus; Møller, Ditte S.
Afiliación
  • Tvilum M; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.
  • Lutz CM; Danish Center for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark.
  • Knap MM; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.
  • Hoffmann L; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.
  • Khalil AA; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.
  • Holt MI; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
  • Kandi M; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.
  • Schmidt HH; Department of Clinical Genetics, Sygehus Lillebaelt, Vejle, Denmark.
  • Appelt AL; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.
  • Alber M; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.
  • Møller DS; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK.
Acta Oncol ; 62(11): 1426-1432, 2023 Nov.
Article en En | MEDLINE | ID: mdl-37796133
BACKGROUND: Adenocarcinoma (AC) and squamous cell carcinoma (SCC) are the most frequent histological subtypes of non-small cell lung cancer (NSCLC). The aim of this study was to investigate how patients with AC and SCC benefit from image-guided adaptive radiotherapy (ART) with tumour match. MATERIAL AND METHODS: Consecutive patients diagnosed with AC or SCC of the lung treated with definitive chemo-radiotherapy before and after the implementation of ART and tumour match were retrospectively included for analyses. Data collection included baseline patient and treatment characteristics in addition to clinical data on radiation pneumonitis (RP), failure, and survival. Patients were divided into four categories based on their histology and treatment before (n = 173 [89 AC and 84 SCC]) and after implementation of ART (n = 240 [141 AC and 99 SCC]). RESULTS: Median follow-up was 5.7 years for AC and 6.3 years for SCC. Mean lung dose decreased for both histologies with ART, whereas mean heart dose only decreased for patients with AC. Incidences of grade 3 and 5 RP decreased for both histologies with ART. Loco-regional failure (LRF) rates decreased significantly for patients with SCC after ART (p = .04), no significant difference was observed for AC. Overall survival (OS) increased significantly for SCC after ART (p < .01): the 2-year OS increased from 31.0% (95% confidence interval [CI] [22.5-42.6]) to 54.5% (95% CI [45.6-65.3]). No significant effect on OS was observed for patients with AC. CONCLUSION: ART and tumour match in the radiotherapeutic treatment of patients with locally advanced NSCLC primarily led to decreased LRF and improved OS for patients with SCC.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Escamosas / Adenocarcinoma / Carcinoma de Pulmón de Células no Pequeñas / Neoplasias Pulmonares Límite: Humans Idioma: En Revista: Acta Oncol Asunto de la revista: NEOPLASIAS Año: 2023 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Suecia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Escamosas / Adenocarcinoma / Carcinoma de Pulmón de Células no Pequeñas / Neoplasias Pulmonares Límite: Humans Idioma: En Revista: Acta Oncol Asunto de la revista: NEOPLASIAS Año: 2023 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Suecia