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High-grade transformation of a polymorphous adenocarcinoma of the salivary gland: a case report and review of the literature.
Miserocchi, Giacomo; Bassi, Massimo; De Luca, Giovanni; Calpona, Sebastiano; De Rosa, Francesco; Bongiovanni, Alberto; Parisi, Elisabetta; Di Menna, Giandomenico; De Vita, Alessandro; Liverani, Chiara; Spadazzi, Chiara; Cocchi, Claudia; Vanni, Silvia; Capelli, Laura; Magnani, Massimo; Meccariello, Giuseppe; Vicini, Claudio; Campobassi, Angelo; Mercatali, Laura; Ibrahim, Toni.
Afiliación
  • Miserocchi G; Preclinic and Osteoncology Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.
  • Bassi M; Maxillofacial Surgery Unit, "Bufalini Hospital", Azienda Unità Sanitaria Locale (AUSL) Romagna, Cesena, Italy.
  • De Luca G; Pathology Unit, "Bufalini" Hospital, Azienda Unità Sanitaria Locale (AUSL) Romagna, Cesena, Italy.
  • Calpona S; Preclinic and Osteoncology Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.
  • De Rosa F; Immunotherapy, Cell Therapy and Biobank, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.
  • Bongiovanni A; Preclinic and Osteoncology Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.
  • Parisi E; Radiotherapy Department, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), IRCCS, Meldola, Italy.
  • Di Menna G; Department of Medical Oncology, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.
  • De Vita A; Preclinic and Osteoncology Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.
  • Liverani C; Preclinic and Osteoncology Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.
  • Spadazzi C; Preclinic and Osteoncology Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.
  • Cocchi C; Preclinic and Osteoncology Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.
  • Vanni S; Preclinic and Osteoncology Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.
  • Capelli L; Biosciences Laboratory, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.
  • Magnani M; Department of Head-Neck Surgery Azienda Unità Sanitaria Locale (AUSL) Romagna, Ear Nose Throat (ENT) Unit, Bufalini Hospital, Cesena, Italy.
  • Meccariello G; Otolaryngology and Head-Neck Surgery Unit, Department of Head-Neck Surgeries, Morgagni Pierantoni Hospital, Azienda USL della Romagna, Forlì, Italy.
  • Vicini C; Otolaryngology and Head-Neck Surgery Unit, Department of Head-Neck Surgeries, Morgagni Pierantoni Hospital, Azienda USL della Romagna, Forlì, Italy.
  • Campobassi A; Maxillofacial Surgery Unit, "Bufalini Hospital", Azienda Unità Sanitaria Locale (AUSL) Romagna, Cesena, Italy.
  • Mercatali L; Preclinic and Osteoncology Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.
  • Ibrahim T; Preclinic and Osteoncology Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.
Front Oncol ; 13: 1245043, 2023.
Article en En | MEDLINE | ID: mdl-37795450
Background: Polymorphous adenocarcinoma (PAC) represents the second most widespread neoplasm of the minor salivary glands. These tumors rarely develop a histological progression from low-grade to high-grade malignancy, named "high-grade transformation" (HGT). Only nine cases are described in literature. Case description: Here, we describe the case of a 76-year-old male patient with a PAC recurrence of the oral floor displaying HGT, and we explore the tumor cytomorphological features, genomic profiling, and the patient's clinical management. The tumor mass was characterized by poorly atypical cellular elements with vesicular nuclei and comedonecrosis foci. The growth pattern was predominantly solid, tubular, and cribriform. The lesion did not show microsatellite instability or targeted molecular alterations. The case was successfully treated with radical surgery followed by radiotherapy. Conclusion: We report for the first time the recurrence of a PAC with HGT arising in the oral floor after 20 years from the primary lesion. These preliminary data and the literature analysis enhance the knowledge of this extremely rare disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Oncol Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Oncol Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza