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The Comparative Study of the Administration of the Combination Preparation of Isoflavones and Hyaluronic Acid in Menopausal Women for the Treatment of the Symptoms of Menopause, Urogenital Atrophy and Oteoporosis in Relation to Existing Hormone Replacement Therapies.
Chalkidou, Anna; Oikonomou, Efthimios; Lambrinos, Dimitrios; Bothou, Anastasia; Kyriakou, Dimitrios; Nikolettos, Konstantinos; Marinos, Georgios; Iatrakis, Georgios; Zervoudis, Stefanos; Nikolettos, Nikolaos; Tsikouras, Panagiotis.
Afiliación
  • Chalkidou A; Department of Obstetrics and Gynecology,Democritus Univesity of Thrace, Greece.
  • Oikonomou E; Department of Obstetrics and Gynecology,Democritus Univesity of Thrace, Greece.
  • Lambrinos D; Neonatal Intensive Care Unit of University Hospital Alexandroupolis, Greece.
  • Bothou A; Emergency Care Department, Laiko General Hospital, Athens, Greece.
  • Kyriakou D; Department of Obstetrics and Gynecology,Democritus Univesity of Thrace, Greece.
  • Nikolettos K; Department of Obstetrics and Gynecology,Democritus Univesity of Thrace, Greece.
  • Marinos G; Department of Obstetrics and Gynecology,Democritus Univesity of Thrace, Greece.
  • Iatrakis G; Georgios Marinos, Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
  • Zervoudis S; Department of Obstetrics and Gynecology,Democritus Univesity of Thrace, Greece.
  • Nikolettos N; Department of Obstetrics and Gynecology,Democritus Univesity of Thrace, Greece.
  • Tsikouras P; Department of Obstetrics and Gynecology,Democritus Univesity of Thrace, Greece.
Mater Sociomed ; 35(3): 206-214, 2023 Sep.
Article en En | MEDLINE | ID: mdl-37795159
Background: Menopause is characterized by a series of symptoms and effects from the various systems and organs, for which, the decline in estrogen production from the ovaries is considered responsible. Objective: The aim of this study was to make comparative study of the administration of the combination preparation of isoflavones and hyaluronic acid in menopausal women for the treatment of the symptoms of menopause, urogenital atrophy and osteoporosis in relation to existing hormone replacement therapies. Methods: In this five-year, double-blind, placebo-controlled clinical study, a total of 274 postmenopausal women were enrolled and classified into three groups. Participants in group A, were 96 women who did not receive Hormone Replacement Therapy (HRT), in the second group, 92 received daily treatment with tibolone (2.5 mg) as monotherapy, and in the third group, 86 received treatment with a pharmaceutical formulation of hyaluronic acid 120 mg and isoflavones. MF11RCE 80 mg. Results: In the postmenopausal women of our study, a significant reduction of postmenopausal symptoms was found in both groups B and C of participants who received hormone replacement preparations compared to group A who did not receive HRT. Furthermore, no difference in efficacy was observed between the administered preparations of isoflavones and tibolone. Conclusion: The combination of isoflavones and hyaluronic acid has the same efficacy as tibolone in menopausal symptoms.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials / Diagnostic_studies Idioma: En Revista: Mater Sociomed Año: 2023 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Bosnia-Herzegovina
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials / Diagnostic_studies Idioma: En Revista: Mater Sociomed Año: 2023 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Bosnia-Herzegovina