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Alveolar cleft reconstruction using bone marrow aspirate concentrate and iliac cancellous bone: A 12-month randomized clinical study.
Shabaan, Alshaimaa Ahmed; Salahuddin, Ahmad; Aboulmagd, Inass; Ragab, Reham; Salah, Khaled Amr; Rashid, Adel; Ayad, Haytham Mohamed; El Aty Ahmed, Walaa Abd; Refahee, Shaimaa Mohsen.
Afiliación
  • Shabaan AA; Oral & Maxillofacial Surgery Department, Faculty of Dentistry, Fayoum University, Fayoum, 63511, Egypt.
  • Salahuddin A; Biochemistry Department, Faculty of Pharmacy, Damanhour University, Damanhour, Egypt.
  • Aboulmagd I; Biochemistry Department, Faculty of Pharmacy, Al-Ayen university, Nasiriyah, Iraq.
  • Ragab R; Oral & Maxillofacial Radiology, Faculty of Dentistry, Fayoum University, Fayoum, 63511, Egypt.
  • Salah KA; Biomedical Informatics and Medical Statistics Department, Medical Research Institute, Alexandria University, Alexandria, Egypt.
  • Rashid A; Oral and Maxillofacial Surgery, Faculty of Dentistry, Cairo University, Cairo, 11111, Egypt.
  • Ayad HM; Orthodontics, Faculty of Dentistry, Fayoum University, Fayoum, 63511, Egypt.
  • El Aty Ahmed WA; Oral & Maxillofacial Surgery Department, Faculty of Dentistry, Fayoum University, Fayoum, 63511, Egypt.
  • Refahee SM; Oral and Maxillofacial Radiology, Faculty of Dentistry, Cairo University, Cairo, 11111, Egypt.
Clin Oral Investig ; 27(11): 6667-6675, 2023 Nov.
Article en En | MEDLINE | ID: mdl-37794139
OBJECTIVE: This study aimed to compare the bone density and volume in patients with alveolar cleft reconstructions utilizing bone marrow aspirate concentrate with iliac graft versus iliac graft alone. MATERIAL AND METHODS: Thirty-six patients with unilateral alveolar cleft were randomly allocated into either an intervention group receiving an iliac bone graft mixed with bone marrow concentrate or a control group receiving an iliac bone graft. Cone beam CT was obtained preoperative, 6 and 12 months postoperatively to assess the bone density of the graft and bone volume of the alveolar defect, and then, the bone loss ratio was calculated. RESULTS: Bone volume and bone density demonstrated a statistically significant increase in the intervention group at 6 and 12 months. In contrast, the bone loss ratio decreased significantly in the intervention group throughout the follow-up period. CONCLUSION: A combination of bone marrow concentrate and iliac cancellous bone in alveolar cleft reconstruction may improve bone densities and volume in addition to decreasing graft loss rate. CLINICAL SIGNIFICANCE: Using of bone marrow aspirate concentrate will decrease the amount of the graft needed and decrease the ratio of bone loss at the grafted site by the time. Trial registration ClinicalTrials.org ( NCT04414423 ) 4/6/2020.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Labio Leporino / Fisura del Paladar / Injerto de Hueso Alveolar Tipo de estudio: Clinical_trials Límite: Humans Idioma: En Revista: Clin Oral Investig Asunto de la revista: ODONTOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Labio Leporino / Fisura del Paladar / Injerto de Hueso Alveolar Tipo de estudio: Clinical_trials Límite: Humans Idioma: En Revista: Clin Oral Investig Asunto de la revista: ODONTOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Alemania