Your browser doesn't support javascript.
loading
Immune profile of adipose tissue from youth with obesity and asthma.
Reichenbach, Anna; O'Brien, Wade; Duran, Sarai; Authelet, Kayla J; Freishtat, Robert J; Nadler, Evan P; Rastogi, Deepa.
Afiliación
  • Reichenbach A; Children's National Research Institute, Children's National Hospital, Washington, DC, USA.
  • O'Brien W; Children's National Research Institute, Children's National Hospital, Washington, DC, USA.
  • Duran S; Children's National Research Institute, Children's National Hospital, Washington, DC, USA.
  • Authelet KJ; George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
  • Freishtat RJ; Children's National Research Institute, Children's National Hospital, Washington, DC, USA.
  • Nadler EP; George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
  • Rastogi D; Children's National Research Institute, Children's National Hospital, Washington, DC, USA.
Pediatr Obes ; 19(1): e13078, 2024 Jan.
Article en En | MEDLINE | ID: mdl-37793645
ABSTRACT

BACKGROUND:

Obesity is a risk factor for paediatric asthma. Obesity-mediated systemic inflammation correlates with metabolic dysregulation; both are associated with asthma burden. However, adipose tissue inflammation is not defined in obesity-related asthma.

OBJECTIVE:

Define adipose tissue inflammation and its association with metabolic measures in paediatric obesity-related asthma.

METHODS:

Cellular profile of stromal vascular fraction from visceral adipose tissue (VAT) from youth with obesity-related asthma (n = 14) and obesity without asthma (n = 23) was analyzed using flow cytometry and correlated with metabolic measures.

RESULTS:

Compared to youth without asthma, VAT from youth with obesity-related asthma was enriched for leukocytes and macrophages, including M1 and dual M1M2 cells, but did not differ for CD4+ lymphocytes, and endothelial cells, their progenitors, and preadipocytes. M1 macrophage counts positively correlated with glucose, while M1M2 cells, CD4+ lymphocytes, and their subsets negatively correlated with high-density lipoprotein, in youth with obesity without asthma, but not among those with obesity-related asthma.

CONCLUSIONS:

Enrichment of macrophage-mediated inflammation in VAT from youth with obesity-related asthma supports its role in systemic inflammation linked with asthma morbidity. Lack of correlation of VAT cells with metabolic dysregulation in youth with obesity-related asthma identifies a need to define distinguishing factors associated with VAT inflammation in obesity-related asthma.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Asma / Resistencia a la Insulina Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adolescent / Child / Humans Idioma: En Revista: Pediatr Obes Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Asma / Resistencia a la Insulina Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adolescent / Child / Humans Idioma: En Revista: Pediatr Obes Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido