Proline-rich transmembrane protein 2 knock-in mice present dopamine-dependent motor deficits.

Hatta, Daisuke; Kanamoto, Kaito; Makiya, Shiho; Watanabe, Kaori; Kishino, Tatsuya; Kinoshita, Akira; Yoshiura, Koh-Ichiro; Kurotaki, Naohiro; Shirotani, Keiro; Iwata, Nobuhisa

Hatta, Daisuke; Kanamoto, Kaito; Makiya, Shiho; Watanabe, Kaori; Kishino, Tatsuya; Kinoshita, Akira; Yoshiura, Koh-Ichiro; Kurotaki, Naohiro; Shirotani, Keiro; Iwata, Nobuhisa.

Afiliación

Hatta D; Department of Genome-Based Drug Discovery, Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki-shi, Nagasaki 852-8521, Japan.
Kanamoto K; Department of Genome-Based Drug Discovery, Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki-shi, Nagasaki 852-8521, Japan.
Makiya S; Department of Genome-Based Drug Discovery, Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki-shi, Nagasaki 852-8521, Japan.
Watanabe K; Department of Genome-Based Drug Discovery, Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki-shi, Nagasaki 852-8521, Japan.
Kishino T; Division of Functional Genomics, Research Center for Advanced Genomics, Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki-shi, Nagasaki 852-8523, Japan.
Kinoshita A; Leading Medical Research Core Unit, Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki-shi, Nagasaki 852-8523, Japan.
Yoshiura KI; Department of Human Genetics, Atomic Bomb Disease Institute, Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki-shi, Nagasaki 852-8523, Japan.
Kurotaki N; Leading Medical Research Core Unit, Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki-shi, Nagasaki 852-8523, Japan.
Shirotani K; Department of Human Genetics, Atomic Bomb Disease Institute, Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki-shi, Nagasaki 852-8523, Japan.
Iwata N; Leading Medical Research Core Unit, Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki-shi, Nagasaki 852-8523, Japan.

J Biochem ; 174(6): 561-570, 2023 Nov 30.

Article en En | MEDLINE | ID: mdl-37793168

Asunto(s)

Dopamina; Distonía; Animales; Humanos; Ratones; Distonía/genética; Proteínas de la Membrana/genética; Mutación

Palabras clave

l-dopa; Prrt2; dopamine; paroxysmal kinesigenic dyskinesia; rotarod.Abbreviations: BFIE, benign familial infantile epilepsy; BG, basal ganglia; DA, dopamine; gRNA, guide ribonucleic acid; KI, knock-in; Kif26b, kinesin family member 26b; KLH, Keyhole Limpet Hemocyanin; LID, l-dopa-induced dyskinesia; MBS, m-maleimidobenzoyl-N-hydroxysuccinimide ester; NMD, nonsense-mediated mRNA decay; PKD, paroxysmal kinesigenic dyskinesia; PRRT2, proline-rich transmembrane protein 2; SNARE, soluble N-ethylmaleimide-sensitive factor attachment protein receptor

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dopamina / Distonía Límite: Animals / Humans Idioma: En Revista: J Biochem Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido

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